Search Results

Overview

Uniprot IDP04637
Protein NameCellular tumor antigen p53
Gene NameTP53
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
120 FLHSGTAKSVTCTYS
370 RAHSSHLKSKKGQST

Function

Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492)

Protein Sequence

10 MEEPQSDPSV 20 EPPLSQETFS 30 DLWKLLPENN 40 VLSPLPSQAM 50 DDLMLSPDDI 60 EQWFTEDPGP 70 DEAPRMPEAA 80 PPVAPAPAAP 90 TPAAPAPAPS 100 WPLSSSVPSQ 110 KTYQGSYGFR 120 LGFLHSGTAK 130 SVTCTYSPAL 140 NKMFCQLAKT 150 CPVQLWVDST 160 PPPGTRVRAM 170 AIYKQSQHMT 180 EVVRRCPHHE 190 RCSDSDGLAP 200 PQHLIRVEGN 210 LRVEYLDDRN 220 TFRHSVVVPY 230 EPPEVGSDCT 240 TIHYNYMCNS 250 SCMGGMNRRP 260 ILTIITLEDS 270 SGNLLGRNSF 280 EVRVCACPGR 290 DRRTEEENLR 300 KKGEPHHELP 310 PGSTKRALPN 320 NTSSSPQPKK 330 KPLDGEYFTL 340 QIRGRERFEM 350 FRELNEALEL 360 KDAQAGKEPG 370 GSRAHSSHLK 380 SKKGQSTSRH 390 KKLMFKTEGP DSD

Gene Ontology

Classification GO ID Description
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0001094 TFIID-class transcription factor complex binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0001223 transcription coactivator binding
Molecular Function GO:0031625 ubiquitin protein ligase binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006914 autophagy
Biological Process GO:0048539 bone marrow development
Biological Process GO:0072717 cellular response to actinomycin D
Biological Process GO:0071480 cellular response to gamma radiation
Biological Process GO:0042149 cellular response to glucose starvation
Biological Process GO:0071456 cellular response to hypoxia
Biological Process GO:0071479 cellular response to ionizing radiation
Biological Process GO:0034644 cellular response to UV
Biological Process GO:0071466 cellular response to xenobiotic stimulus
Biological Process GO:0090398 cellular senescence
Biological Process GO:0048512 circadian behavior
Biological Process GO:0008340 determination of adult lifespan
Biological Process GO:0006974 DNA damage response
Biological Process GO:0030330 DNA damage response, signal transduction by p53 class mediator
Biological Process GO:0043153 entrainment of circadian clock by photoperiod
Biological Process GO:0006983 ER overload response
Biological Process GO:0002244 hematopoietic progenitor cell differentiation
Biological Process GO:0060218 hematopoietic stem cell differentiation
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0097193 intrinsic apoptotic signaling pathway
Biological Process GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Biological Process GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Biological Process GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Biological Process GO:0031571 mitotic G1 DNA damage checkpoint signaling
Biological Process GO:0009299 mRNA transcription
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0048147 negative regulation of fibroblast proliferation
Biological Process GO:1903451 negative regulation of G1 to G0 transition
Biological Process GO:0051097 negative regulation of helicase activity
Biological Process GO:1905856 negative regulation of pentose-phosphate shunt
Biological Process GO:0032211 negative regulation of telomere maintenance via telomerase
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006289 nucleotide-excision repair
Biological Process GO:0097252 oligodendrocyte apoptotic process
Biological Process GO:0090403 oxidative stress-induced premature senescence
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:2000774 positive regulation of cellular senescence
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:1900119 positive regulation of execution phase of apoptosis
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Biological Process GO:1902895 positive regulation of miRNA transcription
Biological Process GO:0062100 positive regulation of programmed necrotic cell death
Biological Process GO:2000379 positive regulation of reactive oxygen species metabolic process
Biological Process GO:0090200 positive regulation of release of cytochrome c from mitochondria
Biological Process GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
Biological Process GO:0070245 positive regulation of thymocyte apoptotic process
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0051262 protein tetramerization
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0007265 Ras protein signal transduction
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:1902749 regulation of cell cycle G2/M phase transition
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0090399 replicative senescence
Biological Process GO:0046677 response to antibiotic
Biological Process GO:0010332 response to gamma radiation
Biological Process GO:0072331 signal transduction by p53 class mediator
Biological Process GO:0045815 transcription initiation-coupled chromatin remodeling
Biological Process GO:0033209 tumor necrosis factor-mediated signaling pathway
Biological Process GO:0060333 type II interferon-mediated signaling pathway
Biological Process GO:0016032 viral process
Cellular Component GO:0005813 centrosome
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016605 PML body
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0071889 14-3-3 protein binding
Molecular Function GO:0036310 ATP-dependent DNA/DNA annealing activity
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0000987 cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0005507 copper ion binding
Molecular Function GO:0001046 core promoter sequence-specific DNA binding
Molecular Function GO:0097718 disordered domain specific binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0140296 general transcription initiation factor binding
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0097371 MDM2/MDM4 family protein binding
Molecular Function GO:0140693 molecular condensate scaffold activity
Molecular Function GO:0140677 molecular function activator activity
Molecular Function GO:0003730 mRNA 3'-UTR binding
Molecular Function GO:0002039 p53 binding
Molecular Function GO:1990841 promoter-specific chromatin binding
Molecular Function GO:0002020 protease binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0051721 protein phosphatase 2A binding
Molecular Function GO:0051087 protein-folding chaperone binding
Molecular Function GO:0030971 receptor tyrosine kinase binding

Reference

PMID: N/A