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Overview

Uniprot IDP04642
Protein NameL-lactate dehydrogenase A chain
Gene NameLdha
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
155 WKISGFPKNRVIGSG
224 QLGTDADKEQWKDVH
228 DADKEQWKDVHKQVV
232 EQWKDVHKQVVDSAY
243 DSAYEVIKLKGYTSW
278 HPISTMIKGLYGIKE
318 DEEARLKKSADTLWG
5 ***MAALKDQLIVNL
59 DVIEDKLKGEMMDLQ
73 QHGSLFLKTPKIVSS
76 SLFLKTPKIVSSKDY
81 TPKIVSSKDYSVTAN

Function

Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)

Protein Sequence

10 MAALKDQLIV 20 NLLKEEQVPQ 30 NKITVVGVGA 40 VGMACAISIL 50 MKDLADELAL 60 VDVIEDKLKG 70 EMMDLQHGSL 80 FLKTPKIVSS 90 KDYSVTANSK 100 LVIITAGARQ 110 QEGESRLNLV 120 QRNVNIFKFI 130 IPNVVKYSPQ 140 CKLLIVSNPV 150 DILTYVAWKI 160 SGFPKNRVIG 170 SGCNLDSARF 180 RYLMGERLGV 190 HPLSCHGWVL 200 GEHGDSSVPV 210 WSGVNVAGVS 220 LKSLNPQLGT 230 DADKEQWKDV 240 HKQVVDSAYE 250 VIKLKGYTSW 260 AIGLSVADLA 270 ESIMKNLRRV 280 HPISTMIKGL 290 YGIKEDVFLS 300 VPCILGQNGI 310 SDVVKVTLTP 320 DEEARLKKSA 330 DTLWGIQKEL QF

Gene Ontology

Classification GO ID Description
Biological Process GO:0001666 response to hypoxia
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:1990204 oxidoreductase complex
Cellular Component GO:0035686 sperm fibrous sheath
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019900 kinase binding
Molecular Function GO:0004459 L-lactate dehydrogenase (NAD+) activity
Molecular Function GO:0004457 lactate dehydrogenase activity
Molecular Function GO:0051287 NAD binding
Biological Process GO:1904628 cellular response to phorbol 13-acetate 12-myristate
Biological Process GO:0019661 homolactic fermentation
Biological Process GO:0006089 lactate metabolic process
Biological Process GO:0001889 liver development
Biological Process GO:0019674 NAD+ metabolic process
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0042867 pyruvate catabolic process
Biological Process GO:0051591 response to cAMP
Biological Process GO:0043627 response to estrogen
Biological Process GO:0009749 response to glucose
Biological Process GO:0042542 response to hydrogen peroxide
Biological Process GO:0007584 response to nutrient
Biological Process GO:0009410 response to xenobiotic stimulus
Biological Process GO:0007519 skeletal muscle tissue development

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.