Search Results
Overview
| Uniprot ID | P04731 |
|---|---|
| Protein Name | Metallothionein-1A |
| Gene Name | MT1A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 31 | CKCTSCKKSCCSCCP |
| 51 | CAQGCICKGASEKCS |
Function
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids
Protein Sequence
10
MDPNCSCATG
20
GSCTCTGSCK
30
CKECKCTSCK
40
KSCCSCCPMS
50
CAKCAQGCIC
60
KGASEKCSCC
A
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0071276 | cellular response to cadmium ion |
| Biological Process | GO:0071280 | cellular response to copper ion |
| Biological Process | GO:0071294 | cellular response to zinc ion |
| Biological Process | GO:0010273 | detoxification of copper ion |
| Biological Process | GO:0006882 | intracellular zinc ion homeostasis |
| Biological Process | GO:0045926 | negative regulation of growth |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.