Search Results

Overview

Uniprot ID	P04775
Protein Name	Sodium channel protein type 2 subunit alpha
Gene Name	Scn2a
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
1903	ITTTLKRKQEEVSAI

Function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity)

Protein Sequence

10 MARSVLVPPG 20 PDSFRFFTRE 30 SLAAIEQRIA 40 EEKAKRPKQE 50 RKDEDDENGP 60 KPNSDLEAGK 70 SLPFIYGDIP 80 PEMVSEPLED 90 LDPYYINKKT 100 FIVLNKGKAI 110 SRFSATSALY 120 ILTPFNPIRK 130 LAIKILVHSL 140 FNVLIMCTIL 150 TNCVFMTMSN 160 PPDWTKNVEY 170 TFTGIYTFES 180 LIKILARGFC 190 LEDFTFLRNP 200 WNWLDFTVIT 210 FAYVTEFVNL 220 GNVSALRTFR 230 VLRALKTISV 240 IPGLKTIVGA 250 LIQSVKKLSD 260 VMILTVFCLS 270 VFALIGLQLF 280 MGNLRNKCLQ 290 WPPDNSTFEI 300 NITSFFNNSL 310 DWNGTAFNRT 320 VNMFNWDEYI 330 EDKSHFYFLE 340 GQNDALLCGN 350 SSDAGQCPEG 360 YICVKAGRNP 370 NYGYTSFDTF 380 SWAFLSLFRL 390 MTQDFWENLY 400 QLTLRAAGKT 410 YMIFFVLVIF 420 LGSFYLINLI 430 LAVVAMAYEE 440 QNQATLEEAE 450 QKEAEFQQML 460 EQLKKQQEEA 470 QAAAAAASAE 480 SRDFSGAGGI 490 GVFSESSSVA 500 SKLSSKSEKE 510 LKNRRKKKKQ 520 KEQAGEEEKE 530 DAVRKSASED 540 SIRKKGFQFS 550 LEGSRLTYEK 560 RFSSPHQSLL 570 SIRGSLFSPR 580 RNSRASLFNF 590 KGRVKDIGSE 600 NDFADDEHST 610 FEDNDSRRDS 620 LFVPHRHGER 630 RPSNVSQASR 640 ASRGIPTLPM 650 NGKMHSAVDC 660 NGVVSLVGGP 670 SALTSPVGQL 680 LPEGTTTETE 690 IRKRRSSSYH 700 VSMDLLEDPS 710 RQRAMSMASI 720 LTNTMEELEE 730 SRQKCPPCWY 740 KFANMCLIWD 750 CCKPWLKVKH 760 VVNLVVMDPF 770 VDLAITICIV 780 LNTLFMAMEH 790 YPMTEQFSSV 800 LSVGNLVFTG 810 IFTAEMFLKI 820 IAMDPYYYFQ 830 EGWNIFDGFI 840 VSLSLMELGL 850 ANVEGLSVLR 860 SFRLLRVFKL 870 AKSWPTLNML 880 IKIIGNSVGA 890 LGNLTLVLAI 900 IVFIFAVVGM 910 QLFGKSYKEC 920 VCKISNDCEL 930 PRWHMHHFFH 940 SFLIVFRVLC 950 GEWIETMWDC 960 MEVAGQTMCL 970 TVFMMVMVIG 980 NLVVLNLFLA 990 LLLSSFSSDN 1000 LAATDDDNEM 1010 NNLQIAVGRM 1020 QKGIDFVKRK 1030 IREFIQKAFV 1040 RKQKALDEIK 1050 PLEDLNNKKD 1060 SCISNHTTIE 1070 IGKDLNYLKD 1080 GNGTTSGIGS 1090 SVEKYVVDES 1100 DYMSFINNPS 1110 LTVTVPIALG 1120 ESDFENLNTE 1130 EFSSESDMEE 1140 SKEKLNATSS 1150 SEGSTVDIGA 1160 PAEGEQPEAE 1170 PEESLEPEAC 1180 FTEDCVRKFK 1190 CCQISIEEGK 1200 GKLWWNLRKT 1210 CYKIVEHNWF 1220 ETFIVFMILL 1230 SSGALAFEDI 1240 YIEQRKTIKT 1250 MLEYADKVFT 1260 YIFILEMLLK 1270 WVAYGFQMYF 1280 TNAWCWLDFL 1290 IVDVSLVSLT 1300 ANALGYSELG 1310 AIKSLRTLRA 1320 LRPLRALSRF 1330 EGMRVVVNAL 1340 LGAIPSIMNV 1350 LLVCLIFWLI 1360 FSIMGVNLFA 1370 GKFYHCINYT 1380 TGEMFDVSVV 1390 NNYSECQALI 1400 ESNQTARWKN 1410 VKVNFDNVGL 1420 GYLSLLQVAT 1430 FKGWMDIMYA 1440 AVDSRNVELQ 1450 PKYEDNLYMY 1460 LYFVIFIIFG 1470 SFFTLNLFIG 1480 VIIDNFNQQK 1490 KKFGGQDIFM 1500 TEEQKKYYNA 1510 MKKLGSKKPQ 1520 KPIPRPANKF 1530 QGMVFDFVTK 1540 QVFDISIMIL 1550 ICLNMVTMMV 1560 ETDDQSQEMT 1570 NILYWINLVF 1580 IVLFTGECVL 1590 KLISLRHYYF 1600 TIGWNIFDFV 1610 VVILSIVGMF 1620 LAELIEKYFV 1630 SPTLFRVIRL 1640 ARIGRILRLI 1650 KGAKGIRTLL 1660 FALMMSLPAL 1670 FNIGLLLFLV 1680 MFIYAIFGMS 1690 NFAYVKREVG 1700 IDDMFNFETF 1710 GNSMICLFQI 1720 TTSAGWDGLL 1730 APILNSGPPD 1740 CDPEKDHPGS 1750 SVKGDCGNPS 1760 VGIFFFVSYI 1770 IISFLVVVNM 1780 YIAVILENFS 1790 VATEESAEPL 1800 SEDDFEMFYE 1810 VWEKFDPDAT 1820 QFIEFCKLSD 1830 FAAALDPPLL 1840 IAKPNKVQLI 1850 AMDLPMVSGD 1860 RIHCLDILFA 1870 FTKRVLGESG 1880 EMDALRIQME 1890 ERFMASNPSK 1900 VSYEPITTTL 1910 KRKQEEVSAI 1920 VIQRAYRRYL 1930 LKQKVKKVSS 1940 IYKKDKGKED 1950 EGTPIKEDII 1960 TDKLNENSTP 1970 EKTDVTPSTT 1980 SPPSYDSVTK 1990 PEKEKFEKDK 2000 SEKEDKGKDI RESKK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030424	axon
Cellular Component	GO:0043194	axon initial segment
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0014704	intercalated disc
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0033268	node of Ranvier
Cellular Component	GO:0033270	paranode region of axon
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0042734	presynaptic membrane
Cellular Component	GO:0030315	T-tubule
Cellular Component	GO:0001518	voltage-gated sodium channel complex
Molecular Function	GO:0005516	calmodulin binding
Molecular Function	GO:0043522	leucine zipper domain binding
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
Molecular Function	GO:0005248	voltage-gated sodium channel activity
Biological Process	GO:0061564	axon development
Biological Process	GO:0071456	cellular response to hypoxia
Biological Process	GO:0021987	cerebral cortex development
Biological Process	GO:0022038	corpus callosum development
Biological Process	GO:0021542	dentate gyrus development
Biological Process	GO:0008340	determination of adult lifespan
Biological Process	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress
Biological Process	GO:0086010	membrane depolarization during action potential
Biological Process	GO:0007613	memory
Biological Process	GO:0042552	myelination
Biological Process	GO:0021675	nerve development
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0051402	neuron apoptotic process
Biological Process	GO:0019228	neuronal action potential
Biological Process	GO:0021554	optic nerve development
Biological Process	GO:0019233	sensory perception of pain
Biological Process	GO:0035725	sodium ion transmembrane transport
Biological Process	GO:0006814	sodium ion transport

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.