Overview
| Uniprot ID | P04798 |
|---|
| Protein Name | Cytochrome P450 1A1 |
|---|
| Gene Name | CYP1A1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 454 |
VIIFGMGKRKCIGET |
Function
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15041462, PubMed:15805301, PubMed:18577768, PubMed:19965576, PubMed:20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15041462, PubMed:15805301, PubMed:18577768, PubMed:19965576, PubMed:20972997). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions (PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15805301). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (PubMed:15041462, PubMed:18577768). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:15041462, PubMed:19965576, PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system (PubMed:20972997). Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (PubMed:15041462). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195)
Protein Sequence
10
MLFPISMSAT
20
EFLLASVIFC
30
LVFWVIRASR
40
PQVPKGLKNP
50
PGPWGWPLIG
60
HMLTLGKNPH
70
LALSRMSQQY
80
GDVLQIRIGS
90
TPVVVLSGLD
100
TIRQALVRQG
110
DDFKGRPDLY
120
TFTLISNGQS
130
MSFSPDSGPV
140
WAARRRLAQN
150
GLKSFSIASD
160
PASSTSCYLE
170
EHVSKEAEVL
180
ISTLQELMAG
190
PGHFNPYRYV
200
VVSVTNVICA
210
ICFGRRYDHN
220
HQELLSLVNL
230
NNNFGEVVGS
240
GNPADFIPIL
250
RYLPNPSLNA
260
FKDLNEKFYS
270
FMQKMVKEHY
280
KTFEKGHIRD
290
ITDSLIEHCQ
300
EKQLDENANV
310
QLSDEKIINI
320
VLDLFGAGFD
330
TVTTAISWSL
340
MYLVMNPRVQ
350
RKIQEELDTV
360
IGRSRRPRLS
370
DRSHLPYMEA
380
FILETFRHSS
390
FVPFTIPHST
400
TRDTSLKGFY
410
IPKGRCVFVN
420
QWQINHDQKL
430
WVNPSEFLPE
440
RFLTPDGAID
450
KVLSEKVIIF
460
GMGKRKCIGE
470
TIARWEVFLF
480
LAILLQRVEF
490
SVPLGVKVDM
500
TPIYGLTMKH
510
ACCEHFQMQL
RS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0008391 |
arachidonate monooxygenase activity |
| Molecular Function |
GO:0032451 |
demethylase activity |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0101020 |
estrogen 16-alpha-hydroxylase activity |
| Molecular Function |
GO:0101021 |
estrogen 2-hydroxylase activity |
| Molecular Function |
GO:0016711 |
flavonoid 3'-monooxygenase activity |
| Molecular Function |
GO:0020037 |
heme binding |
| Molecular Function |
GO:0030544 |
Hsp70 protein binding |
| Molecular Function |
GO:0051879 |
Hsp90 protein binding |
| Molecular Function |
GO:0106256 |
hydroperoxy icosatetraenoate dehydratase activity |
| Molecular Function |
GO:0005506 |
iron ion binding |
| Molecular Function |
GO:0120319 |
long-chain fatty acid omega-1 hydroxylase activity |
| Molecular Function |
GO:0102033 |
long-chain fatty acid omega-hydroxylase activity |
| Molecular Function |
GO:0004497 |
monooxygenase activity |
| Molecular Function |
GO:0016491 |
oxidoreductase activity |
| Molecular Function |
GO:0016679 |
oxidoreductase activity, acting on diphenols and related substances as donors |
| Molecular Function |
GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Molecular Function |
GO:0019825 |
oxygen binding |
| Molecular Function |
GO:0008395 |
steroid hydroxylase activity |
| Molecular Function |
GO:0070576 |
vitamin D 24-hydroxylase activity |
| Biological Process |
GO:0042904 |
9-cis-retinoic acid biosynthetic process |
| Biological Process |
GO:0043010 |
camera-type eye development |
| Biological Process |
GO:0071280 |
cellular response to copper ion |
| Biological Process |
GO:0009804 |
coumarin metabolic process |
| Biological Process |
GO:0019341 |
dibenzo-p-dioxin catabolic process |
| Biological Process |
GO:0048565 |
digestive tract development |
| Biological Process |
GO:0019373 |
epoxygenase P450 pathway |
| Biological Process |
GO:0008210 |
estrogen metabolic process |
| Biological Process |
GO:0009692 |
ethylene metabolic process |
| Biological Process |
GO:0006631 |
fatty acid metabolic process |
| Biological Process |
GO:0009812 |
flavonoid metabolic process |
| Biological Process |
GO:0070365 |
hepatocyte differentiation |
| Biological Process |
GO:0017143 |
insecticide metabolic process |
| Biological Process |
GO:0002933 |
lipid hydroxylation |
| Biological Process |
GO:0042759 |
long-chain fatty acid biosynthetic process |
| Biological Process |
GO:0001676 |
long-chain fatty acid metabolic process |
| Biological Process |
GO:0060137 |
maternal process involved in parturition |
| Biological Process |
GO:0046209 |
nitric oxide metabolic process |
| Biological Process |
GO:0097267 |
omega-hydroxylase P450 pathway |
| Biological Process |
GO:0006778 |
porphyrin-containing compound metabolic process |
| Biological Process |
GO:1900087 |
positive regulation of G1/S transition of mitotic cell cycle |
| Biological Process |
GO:1904612 |
response to 2,3,7,8-tetrachlorodibenzodioxine |
| Biological Process |
GO:1904681 |
response to 3-methylcholanthrene |
| Biological Process |
GO:1904010 |
response to Aroclor 1254 |
| Biological Process |
GO:0046685 |
response to arsenic-containing substance |
| Biological Process |
GO:1901497 |
response to diphenyl ether |
| Biological Process |
GO:0032094 |
response to food |
| Biological Process |
GO:0033595 |
response to genistein |
| Biological Process |
GO:0009635 |
response to herbicide |
| Biological Process |
GO:0055093 |
response to hyperoxia |
| Biological Process |
GO:0001666 |
response to hypoxia |
| Biological Process |
GO:0035902 |
response to immobilization stress |
| Biological Process |
GO:0010041 |
response to iron(III) ion |
| Biological Process |
GO:0032496 |
response to lipopolysaccharide |
| Biological Process |
GO:0009624 |
response to nematode |
| Biological Process |
GO:0033189 |
response to vitamin A |
| Biological Process |
GO:0042572 |
retinol metabolic process |
| Biological Process |
GO:0006694 |
steroid biosynthetic process |
| Biological Process |
GO:0006706 |
steroid catabolic process |
| Biological Process |
GO:0008202 |
steroid metabolic process |
| Biological Process |
GO:0048771 |
tissue remodeling |
| Biological Process |
GO:0009404 |
toxin metabolic process |
| Biological Process |
GO:0042359 |
vitamin D metabolic process |
| Biological Process |
GO:0042178 |
xenobiotic catabolic process |
| Biological Process |
GO:0006805 |
xenobiotic metabolic process |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.