Search Results
Overview
| Uniprot ID | P04818 |
|---|---|
| Protein Name | Thymidylate synthase |
| Gene Name | TYMS |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 77 | EFPLLTTKRVFWKGV |
Function
Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the mitochondrial and nuclear de novo thymidylate biosynthesis pathway
Protein Sequence
10
MPVAGSELPR
20
RPLPPAAQER
30
DAEPRPPHGE
40
LQYLGQIQHI
50
LRCGVRKDDR
60
TGTGTLSVFG
70
MQARYSLRDE
80
FPLLTTKRVF
90
WKGVLEELLW
100
FIKGSTNAKE
110
LSSKGVKIWD
120
ANGSRDFLDS
130
LGFSTREEGD
140
LGPVYGFQWR
150
HFGAEYRDME
160
SDYSGQGVDQ
170
LQRVIDTIKT
180
NPDDRRIIMC
190
AWNPRDLPLM
200
ALPPCHALCQ
210
FYVVNSELSC
220
QLYQRSGDMG
230
LGVPFNIASY
240
ALLTYMIAHI
250
TGLKPGDFIH
260
TLGDAHIYLN
270
HIEPLKIQLQ
280
REPRPFPKLR
290
ILRKVEKIDD
300
FKAEDFQIEG
310
YNPHPTIKME
MAV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005657 | replication fork |
| Molecular Function | GO:0005542 | folic acid binding |
| Molecular Function | GO:0000900 | mRNA regulatory element binding translation repressor activity |
| Molecular Function | GO:1990825 | sequence-specific mRNA binding |
| Molecular Function | GO:0004799 | thymidylate synthase activity |
| Biological Process | GO:0006207 | 'de novo' pyrimidine nucleobase biosynthetic process |
| Biological Process | GO:0071897 | DNA biosynthetic process |
| Biological Process | GO:0006260 | DNA replication |
| Biological Process | GO:0006231 | dTMP biosynthetic process |
| Biological Process | GO:0006235 | dTTP biosynthetic process |
| Biological Process | GO:0032259 | methylation |
| Biological Process | GO:0017148 | negative regulation of translation |
| Biological Process | GO:0035999 | tetrahydrofolate interconversion |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.