Search Results
Overview
| Uniprot ID | P04904 |
|---|---|
| Protein Name | Glutathione S-transferase alpha-3 |
| Gene Name | Gsta3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 141 | PAFEKVLKSHGQDYL |
| 195 | VSNLPTVKKFLQPGS |
| 196 | SNLPTVKKFLQPGSQ |
| 4 | ****MPGKPVLHYFD |
| 84 | TKYNLYGKDMKERAL |
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively (By similarity). Has substantial activity toward aflatoxin B1-8,9-epoxide (By similarity)
Protein Sequence
10
MPGKPVLHYF
20
DGRGRMEPIR
30
WLLAAAGVEF
40
EEQFLKTRDD
50
LARLRNDGSL
60
MFQQVPMVEI
70
DGMKLVQTRA
80
ILNYIATKYN
90
LYGKDMKERA
100
LIDMYAEGVA
110
DLDEIVLHYP
120
YIPPGEKEAS
130
LAKIKDKARN
140
RYFPAFEKVL
150
KSHGQDYLVG
160
NRLSRADVYL
170
VQVLYHVEEL
180
DPSALANFPL
190
LKALRTRVSN
200
LPTVKKFLQP
210
GSQRKPLEDE
220
KCVESAVKIF
S
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0035731 | dinitrosyl-iron complex binding |
| Molecular Function | GO:0005504 | fatty acid binding |
| Molecular Function | GO:0043295 | glutathione binding |
| Molecular Function | GO:0004602 | glutathione peroxidase activity |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Molecular Function | GO:0140104 | molecular carrier activity |
| Molecular Function | GO:0004769 | steroid Delta-isomerase activity |
| Biological Process | GO:0030855 | epithelial cell differentiation |
| Biological Process | GO:1901687 | glutathione derivative biosynthetic process |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0043651 | linoleic acid metabolic process |
| Biological Process | GO:0006693 | prostaglandin metabolic process |
| Biological Process | GO:0031667 | response to nutrient levels |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0042178 | xenobiotic catabolic process |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.