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Overview

Uniprot IDP04905
Protein NameGlutathione S-transferase Mu 1
Gene NameGstm1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
69 YLIDGSRKITQSNAI
83 IMRYLARKHHLCGET

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. The olfactory GST may be crucial for the acuity of the olfactory process (PubMed:8110735, PubMed:8664265). Participates in the formation of novel hepoxilin regioisomers (By similarity)

Protein Sequence

10 MPMILGYWNV 20 RGLTHPIRLL 30 LEYTDSSYEE 40 KRYAMGDAPD 50 YDRSQWLNEK 60 FKLGLDFPNL 70 PYLIDGSRKI 80 TQSNAIMRYL 90 ARKHHLCGET 100 EEERIRADIV 110 ENQVMDNRMQ 120 LIMLCYNPDF 130 EKQKPEFLKT 140 IPEKMKLYSE 150 FLGKRPWFAG 160 DKVTYVDFLA 170 YDILDQYHIF 180 EPKCLDAFPN 190 LKDFLARFEG 200 LKKISAYMKS 210 SRYLSTPIFS KLAQWSNK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0005496 steroid binding
Biological Process GO:0070458 cellular detoxification of nitrogen compound
Biological Process GO:0071466 cellular response to xenobiotic stimulus
Biological Process GO:1901687 glutathione derivative biosynthetic process
Biological Process GO:0006749 glutathione metabolic process
Biological Process GO:0051122 hepoxilin biosynthetic process
Biological Process GO:0018916 nitrobenzene metabolic process
Biological Process GO:0006693 prostaglandin metabolic process
Biological Process GO:0043200 response to amino acid
Biological Process GO:0048678 response to axon injury
Biological Process GO:0045471 response to ethanol
Biological Process GO:0010288 response to lead ion
Biological Process GO:0010038 response to metal ion
Biological Process GO:0007608 sensory perception of smell
Biological Process GO:0042178 xenobiotic catabolic process
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0043295 glutathione binding
Molecular Function GO:0004364 glutathione transferase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0016151 nickel cation binding

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.