Search Results
Overview
| Uniprot ID | P04906 |
|---|---|
| Protein Name | Glutathione S-transferase P |
| Gene Name | Gstp1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 82 | RSLGLYGKDQKEAAL |
Function
Catalyzes conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Acts as a negative regulator of ferroptosis by mediating glutathione conjugation and detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration
Protein Sequence
10
MPPYTIVYFP
20
VRGRCEATRM
30
LLADQGQSWK
40
EEVVTIDVWL
50
QGSLKSTCLY
60
GQLPKFEDGD
70
LTLYQSNAIL
80
RHLGRSLGLY
90
GKDQKEAALV
100
DMVNDGVEDL
110
RCKYGTLIYT
120
NYENGKDDYV
130
KALPGHLKPF
140
ETLLSQNQGG
150
KAFIVGNQIS
160
FADYNLLDLL
170
LVHQVLAPGC
180
LDNFPLLSAY
190
VARLSARPKI
200
KAFLSSPDHL
210
NRPINGNGKQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0032873 | negative regulation of stress-activated MAPK cascade |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0097057 | TRAF2-GSTP1 complex |
| Molecular Function | GO:0035731 | dinitrosyl-iron complex binding |
| Molecular Function | GO:0005504 | fatty acid binding |
| Molecular Function | GO:0004602 | glutathione peroxidase activity |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Molecular Function | GO:0008432 | JUN kinase binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0030291 | protein serine/threonine kinase inhibitor activity |
| Molecular Function | GO:0035730 | S-nitrosoglutathione binding |
| Molecular Function | GO:0015643 | toxic substance binding |
| Biological Process | GO:0031100 | animal organ regeneration |
| Biological Process | GO:0071460 | cellular response to cell-matrix adhesion |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:0071385 | cellular response to glucocorticoid stimulus |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0071222 | cellular response to lipopolysaccharide |
| Biological Process | GO:0035726 | common myeloid progenitor cell proliferation |
| Biological Process | GO:1901687 | glutathione derivative biosynthetic process |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0051122 | hepoxilin biosynthetic process |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0043651 | linoleic acid metabolic process |
| Biological Process | GO:0043124 | negative regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| Biological Process | GO:0110076 | negative regulation of ferroptosis |
| Biological Process | GO:0048147 | negative regulation of fibroblast proliferation |
| Biological Process | GO:0032691 | negative regulation of interleukin-1 beta production |
| Biological Process | GO:0046329 | negative regulation of JNK cascade |
| Biological Process | GO:0070664 | negative regulation of leukocyte proliferation |
| Biological Process | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production |
| Biological Process | GO:0006469 | negative regulation of protein kinase activity |
| Biological Process | GO:0071672 | negative regulation of smooth muscle cell chemotaxis |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032720 | negative regulation of tumor necrosis factor production |
| Biological Process | GO:1904706 | negative regulation of vascular associated smooth muscle cell proliferation |
| Biological Process | GO:0014003 | oligodendrocyte development |
| Biological Process | GO:0032930 | positive regulation of superoxide anion generation |
| Biological Process | GO:0006693 | prostaglandin metabolic process |
| Biological Process | GO:0070372 | regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0032872 | regulation of stress-activated MAPK cascade |
| Biological Process | GO:0043200 | response to amino acid |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0033591 | response to L-ascorbic acid |
| Biological Process | GO:0031667 | response to nutrient levels |
| Biological Process | GO:0000302 | response to reactive oxygen species |
| Biological Process | GO:0009636 | response to toxic substance |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.