Search Results
Overview
| Uniprot ID | P04908 |
|---|---|
| Protein Name | Histone H2A type 1-B/E |
| Gene Name | H2AC4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 10 | GRGKQGGKARAKAKT |
| 119 | IQAVLLPKKTESHHK |
| 120 | QAVLLPKKTESHHKA |
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Protein Sequence
10
MSGRGKQGGK
20
ARAKAKTRSS
30
RAGLQFPVGR
40
VHRLLRKGNY
50
SERVGAGAPV
60
YLAAVLEYLT
70
AEILELAGNA
80
ARDNKKTRII
90
PRHLQLAIRN
100
DEELNKLLGR
110
VTIAQGGVLP
120
NIQAVLLPKK
130
TESHHKAKGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0031507 | heterochromatin formation |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0061644 | protein localization to CENP-A containing chromatin |
Reference
[1] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.