Search Results

Overview

Uniprot IDP05023
Protein NameSodium/potassium-transporting ATPase subunit alpha-1
Gene NameATP1A1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
377 TSTICSDKTGTLTQN
444 QENLPILKRAVAGDA
45 EVSMDDHKLSLDELH
476 EMRERYAKIVEIPFN
487 IPFNSTNKYQLSIHK
508 PQHLLVMKGAPERIL
535 QPLDEELKDAFQNAY
54 SLDELHRKYGTDLSR
605 AVPDAVGKCRSAGIK
625 GDHPITAKAIAKGVG
629 ITAKAIAKGVGIISE
661 QVNPRDAKACVVHGS
671 VVHGSDLKDMTSEQL
727 NDSPALKKADIGVAM
773 RLIFDNLKKSIAYTL
9 GKGVGRDKYEPAAVS

Function

Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients (PubMed:29499166, PubMed:30388404, PubMed:35803952). It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (PubMed:35803952). This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity)

Protein Sequence

10 MGKGVGRDKY 20 EPAAVSEQGD 30 KKGKKGKKDR 40 DMDELKKEVS 50 MDDHKLSLDE 60 LHRKYGTDLS 70 RGLTSARAAE 80 ILARDGPNAL 90 TPPPTTPEWI 100 KFCRQLFGGF 110 SMLLWIGAIL 120 CFLAYSIQAA 130 TEEEPQNDNL 140 YLGVVLSAVV 150 IITGCFSYYQ 160 EAKSSKIMES 170 FKNMVPQQAL 180 VIRNGEKMSI 190 NAEEVVVGDL 200 VEVKGGDRIP 210 ADLRIISANG 220 CKVDNSSLTG 230 ESEPQTRSPD 240 FTNENPLETR 250 NIAFFSTNCV 260 EGTARGIVVY 270 TGDRTVMGRI 280 ATLASGLEGG 290 QTPIAAEIEH 300 FIHIITGVAV 310 FLGVSFFILS 320 LILEYTWLEA 330 VIFLIGIIVA 340 NVPEGLLATV 350 TVCLTLTAKR 360 MARKNCLVKN 370 LEAVETLGST 380 STICSDKTGT 390 LTQNRMTVAH 400 MWFDNQIHEA 410 DTTENQSGVS 420 FDKTSATWLA 430 LSRIAGLCNR 440 AVFQANQENL 450 PILKRAVAGD 460 ASESALLKCI 470 ELCCGSVKEM 480 RERYAKIVEI 490 PFNSTNKYQL 500 SIHKNPNTSE 510 PQHLLVMKGA 520 PERILDRCSS 530 ILLHGKEQPL 540 DEELKDAFQN 550 AYLELGGLGE 560 RVLGFCHLFL 570 PDEQFPEGFQ 580 FDTDDVNFPI 590 DNLCFVGLIS 600 MIDPPRAAVP 610 DAVGKCRSAG 620 IKVIMVTGDH 630 PITAKAIAKG 640 VGIISEGNET 650 VEDIAARLNI 660 PVSQVNPRDA 670 KACVVHGSDL 680 KDMTSEQLDD 690 ILKYHTEIVF 700 ARTSPQQKLI 710 IVEGCQRQGA 720 IVAVTGDGVN 730 DSPALKKADI 740 GVAMGIAGSD 750 VSKQAADMIL 760 LDDNFASIVT 770 GVEEGRLIFD 780 NLKKSIAYTL 790 TSNIPEITPF 800 LIFIIANIPL 810 PLGTVTILCI 820 DLGTDMVPAI 830 SLAYEQAESD 840 IMKRQPRNPK 850 TDKLVNERLI 860 SMAYGQIGMI 870 QALGGFFTYF 880 VILAENGFLP 890 IHLLGLRVDW 900 DDRWINDVED 910 SYGQQWTYEQ 920 RKIVEFTCHT 930 AFFVSIVVVQ 940 WADLVICKTR 950 RNSVFQQGMK 960 NKILIFGLFE 970 ETALAAFLSY 980 CPGMGVALRM 990 YPLKPTWWFC 1000 AFPYSLLIFV 1010 YDEVRKLIIR 1020 RRPGGWVEKE TYY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0030424 axon
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:1903561 extracellular vesicle
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0016328 lateral plasma membrane
Cellular Component GO:0042470 melanosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0031090 organelle membrane
Cellular Component GO:0060342 photoreceptor inner segment membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0005890 sodium:potassium-exchanging ATPase complex
Cellular Component GO:0036126 sperm flagellum
Cellular Component GO:0030315 T-tubule
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0005391 P-type sodium:potassium-exchanging transporter activity
Molecular Function GO:0016791 phosphatase activity
Molecular Function GO:0030955 potassium ion binding
Molecular Function GO:0051087 protein-folding chaperone binding
Molecular Function GO:0031402 sodium ion binding
Molecular Function GO:1990239 steroid hormone binding
Molecular Function GO:0044325 transmembrane transporter binding
Biological Process GO:0086002 cardiac muscle cell action potential involved in contraction
Biological Process GO:0086064 cell communication by electrical coupling involved in cardiac conduction
Biological Process GO:0071383 cellular response to steroid hormone stimulus
Biological Process GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
Biological Process GO:0030007 intracellular potassium ion homeostasis
Biological Process GO:0006883 intracellular sodium ion homeostasis
Biological Process GO:0086009 membrane repolarization
Biological Process GO:0086013 membrane repolarization during cardiac muscle cell action potential
Biological Process GO:0007231 osmosensory signaling pathway
Biological Process GO:1990573 potassium ion import across plasma membrane
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:1902600 proton transmembrane transport
Biological Process GO:0002028 regulation of sodium ion transport
Biological Process GO:0055119 relaxation of cardiac muscle
Biological Process GO:1903416 response to glycoside
Biological Process GO:0036376 sodium ion export across plasma membrane
Biological Process GO:0035725 sodium ion transmembrane transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.