Search Results
Overview
| Uniprot ID | P05026 |
|---|---|
| Protein Name | Sodium/potassium-transporting ATPase subunit beta-1 |
| Gene Name | ATP1B1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 113 | VRFLEKYKDSAQRDD |
| 13 | AKEEGSWKKFIWNSE |
| 134 | GDVPSEPKERGDFNH |
| 14 | KEEGSWKKFIWNSEK |
| 173 | TYGYKEGKPCIIIKL |
| 21 | KFIWNSEKKEFLGRT |
| 216 | LPVQCTGKRDEDKDK |
| 277 | TEIRIECKAYGENIG |
| 288 | ENIGYSEKDRFQGRF |
| 7 | *MARGKAKEEGSWKK |
Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (PubMed:19694409). Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (PubMed:34011520)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0086013 | membrane repolarization during cardiac muscle cell action potential |
| Biological Process | GO:1903288 | positive regulation of potassium ion import across plasma membrane |
| Biological Process | GO:1903278 | positive regulation of sodium ion export across plasma membrane |
| Biological Process | GO:1990573 | potassium ion import across plasma membrane |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0044861 | protein transport into plasma membrane raft |
| Biological Process | GO:1902600 | proton transmembrane transport |
| Biological Process | GO:1903169 | regulation of calcium ion transmembrane transport |
| Biological Process | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0055119 | relaxation of cardiac muscle |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0036376 | sodium ion export across plasma membrane |
| Biological Process | GO:0035725 | sodium ion transmembrane transport |
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:1903561 | extracellular vesicle |
| Cellular Component | GO:0014704 | intercalated disc |
| Cellular Component | GO:0016328 | lateral plasma membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0031090 | organelle membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0005890 | sodium:potassium-exchanging ATPase complex |
| Cellular Component | GO:0036126 | sperm flagellum |
| Cellular Component | GO:0030315 | T-tubule |
| Molecular Function | GO:0001671 | ATPase activator activity |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0023026 | MHC class II protein complex binding |
| Molecular Function | GO:0005391 | P-type sodium:potassium-exchanging transporter activity |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0141109 | transporter activator activity |
| Biological Process | GO:0046034 | ATP metabolic process |
| Biological Process | GO:0060048 | cardiac muscle contraction |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0086064 | cell communication by electrical coupling involved in cardiac conduction |
| Biological Process | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0030007 | intracellular potassium ion homeostasis |
| Biological Process | GO:0006883 | intracellular sodium ion homeostasis |
| Biological Process | GO:0086009 | membrane repolarization |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.