Search Results
Overview
| Uniprot ID | P05027 |
|---|---|
| Protein Name | Sodium/potassium-transporting ATPase subunit beta-1 |
| Gene Name | ATP1B1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 113 | VRFLEKYKDLAQKDD |
| 21 | KFIWNSEKKEFLGRT |
| 216 | LPVHCTGKRDEDKEK |
| 277 | TEIRIECKAYGENIG |
Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1
Protein Sequence
10
MARGKAKEEG
20
SWKKFIWNSE
30
KKEFLGRTGG
40
SWFKILLFYV
50
IFYGCLAGIF
60
IGTIQVMLLT
70
ISEFKPTYQD
80
RVAPPGLTQI
90
PQSQKTEISF
100
RPNDPQSYES
110
YVVSIVRFLE
120
KYKDLAQKDD
130
MIFEDCGNVP
140
SELKERGEYN
150
NERGERKVCR
160
FRLEWLGNCS
170
GLNDETYGYK
180
DGKPCVIIKL
190
NRVLGFKPKP
200
PKNESLETYP
210
VMKYNPYVLP
220
VHCTGKRDED
230
KEKVGTMEYF
240
GLGGYPGFPL
250
QYYPYYGKLL
260
QPKYLQPLMA
270
VQFTNLTMDT
280
EIRIECKAYG
290
ENIGYSEKDR
300
FQGRFDVKIE
VKS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016324 | apical plasma membrane |
| Biological Process | GO:1903288 | positive regulation of potassium ion import across plasma membrane |
| Biological Process | GO:1901381 | positive regulation of potassium ion transmembrane transport |
| Biological Process | GO:1903278 | positive regulation of sodium ion export across plasma membrane |
| Biological Process | GO:1902307 | positive regulation of sodium ion transmembrane transport |
| Biological Process | GO:1990573 | potassium ion import across plasma membrane |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:1902600 | proton transmembrane transport |
| Biological Process | GO:1903169 | regulation of calcium ion transmembrane transport |
| Biological Process | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0055119 | relaxation of cardiac muscle |
| Biological Process | GO:0036376 | sodium ion export across plasma membrane |
| Biological Process | GO:0055085 | transmembrane transport |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0014704 | intercalated disc |
| Cellular Component | GO:0016328 | lateral plasma membrane |
| Cellular Component | GO:0031090 | organelle membrane |
| Cellular Component | GO:0005890 | sodium:potassium-exchanging ATPase complex |
| Cellular Component | GO:0036126 | sperm flagellum |
| Cellular Component | GO:0030315 | T-tubule |
| Molecular Function | GO:0001671 | ATPase activator activity |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0005391 | P-type sodium:potassium-exchanging transporter activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0141109 | transporter activator activity |
| Biological Process | GO:0046034 | ATP metabolic process |
| Biological Process | GO:0060048 | cardiac muscle contraction |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0030007 | intracellular potassium ion homeostasis |
| Biological Process | GO:0006883 | intracellular sodium ion homeostasis |
| Biological Process | GO:0086009 | membrane repolarization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.