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Overview

Uniprot IDP05065
Protein NameFructose-bisphosphate aldolase A
Gene NameAldoa
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
101 FPQVIKSKGGVVGIK
108 KGGVVGIKVDKGVVP
13 PALTPEQKKELADIA
14 ALTPEQKKELADIAH
140 ERCAQYKKDGADFAK
147 KDGADFAKWRCVLKI
230 YLEGTLLKPNMVTPG
28 HRIVAPGKGILAADE
312 ALQASALKAWGGKKE
322 GGKKENLKAAQEEYI
330 AAQEEYIKRALANSL
42 ESTGSIAKRLQSIGT
99 RPFPQVIKSKGGVVG

Function

Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis. In addition, also functions as a scaffolding protein. In response to glucose deprivation, FBP dissociates from aldolase and acts as an adapter that promotes AMP-activated protein kinase (AMPK) activity: mechanistically, associates with transient receptor potential channels TrpV (TRPV1-TRPV4), promoting inhibition of the V-ATPase complex on lysosomes and AMPK activation via the AXIN1-STK11/LKB1 axis

Protein Sequence

10 MPHPYPALTP 20 EQKKELADIA 30 HRIVAPGKGI 40 LAADESTGSI 50 AKRLQSIGTE 60 NTEENRRFYR 70 QLLLTADDRV 80 NPCIGGVILF 90 HETLYQKADD 100 GRPFPQVIKS 110 KGGVVGIKVD 120 KGVVPLAGTN 130 GETTTQGLDG 140 LSERCAQYKK 150 DGADFAKWRC 160 VLKIGEHTPS 170 SLAIMENANV 180 LARYASICQQ 190 NGIVPIVEPE 200 ILPDGDHDLK 210 RCQYVTEKVL 220 AAVYKALSDH 230 HVYLEGTLLK 240 PNMVTPGHAC 250 TQKFSNEEIA 260 MATVTALRRT 270 VPPAVPGVTF 280 LSGGQSEEEA 290 SINLNAINKC 300 PLLKPWALTF 310 SYGRALQASA 320 LKAWGGKKEN 330 LKAAQEEYIK 340 RALANSLACQ 350 GKYTPSGQSG 360 AAASESLFIS NHAY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Biological Process GO:0006754 ATP biosynthetic process
Biological Process GO:0007339 binding of sperm to zona pellucida
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0030388 fructose 1,6-bisphosphate metabolic process
Biological Process GO:0006000 fructose metabolic process
Biological Process GO:0006096 glycolytic process
Biological Process GO:0019242 methylglyoxal biosynthetic process
Biological Process GO:0046716 muscle cell cellular homeostasis
Biological Process GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process GO:0051289 protein homotetramerization
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0043627 response to estrogen
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0035094 response to nicotine
Biological Process GO:0006941 striated muscle contraction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0000792 heterochromatin
Cellular Component GO:0031674 I band
Cellular Component GO:0031430 M band
Cellular Component GO:0061827 sperm head
Molecular Function GO:0008092 cytoskeletal protein binding
Molecular Function GO:0070061 fructose binding
Molecular Function GO:0004332 fructose-bisphosphate aldolase activity
Molecular Function GO:0042802 identical protein binding

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.