Search Results

Overview

Uniprot IDP05089
Protein NameArginase-1
Gene NameARG1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
17 IIGAPFSKGQPRGGV
191 PGEHYILKTLGIKYF
196 ILKTLGIKYFSMTEV
313 LAREGNHKPIDYLNP
33 EGPTVLRKAGLLEKL
41 AGLLEKLKEQECDVK
75 KNPRSVGKASEQLAG
83 ASEQLAGKVAEVKKN

Function

Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys

Protein Sequence

10 MSAKSRTIGI 20 IGAPFSKGQP 30 RGGVEEGPTV 40 LRKAGLLEKL 50 KEQECDVKDY 60 GDLPFADIPN 70 DSPFQIVKNP 80 RSVGKASEQL 90 AGKVAEVKKN 100 GRISLVLGGD 110 HSLAIGSISG 120 HARVHPDLGV 130 IWVDAHTDIN 140 TPLTTTSGNL 150 HGQPVSFLLK 160 ELKGKIPDVP 170 GFSWVTPCIS 180 AKDIVYIGLR 190 DVDPGEHYIL 200 KTLGIKYFSM 210 TEVDRLGIGK 220 VMEETLSYLL 230 GRKKRPIHLS 240 FDVDGLDPSF 250 TPATGTPVVG 260 GLTYREGLYI 270 TEEIYKTGLL 280 SGLDIMEVNP 290 SLGKTPEEVT 300 RTVNTAVAIT 310 LACFGLAREG 320 NHKPIDYLNP PK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035578 azurophil granule lumen
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005634 nucleus
Cellular Component GO:0035580 specific granule lumen
Molecular Function GO:0004053 arginase activity
Molecular Function GO:0030145 manganese ion binding
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0042832 defense response to protozoan
Biological Process GO:0045087 innate immune response
Biological Process GO:0006527 L-arginine catabolic process
Biological Process GO:0046007 negative regulation of activated T cell proliferation
Biological Process GO:0042130 negative regulation of T cell proliferation
Biological Process GO:2000552 negative regulation of T-helper 2 cell cytokine production
Biological Process GO:0060336 negative regulation of type II interferon-mediated signaling pathway
Biological Process GO:0070965 positive regulation of neutrophil mediated killing of fungus
Biological Process GO:0000050 urea cycle

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.