Search Results

Overview

Uniprot IDP05091
Protein NameAldehyde dehydrogenase, mitochondrial
Gene NameALDH2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
155 YYAGWADKYHGKTIP
159 WADKYHGKTIPIDGD
280 AAGSSNLKRVTLELG
355 VGNPFDSKTEQGPQV
368 QVDETQFKKILGYIN
369 VDETQFKKILGYINT
378 LGYINTGKQEGAKLL
383 TGKQEGAKLLCGGGI
426 GPVMQILKFKTIEEV
428 VMQILKFKTIEEVVG
506 LQAYTEVKTVTVKVP
511 EVKTVTVKVPQKNS*
52 WHDAVSRKTFPTVNP

Function

Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage

Protein Sequence

10 MLRAAARFGP 20 RLGRRLLSAA 30 ATQAVPAPNQ 40 QPEVFCNQIF 50 INNEWHDAVS 60 RKTFPTVNPS 70 TGEVICQVAE 80 GDKEDVDKAV 90 KAARAAFQLG 100 SPWRRMDASH 110 RGRLLNRLAD 120 LIERDRTYLA 130 ALETLDNGKP 140 YVISYLVDLD 150 MVLKCLRYYA 160 GWADKYHGKT 170 IPIDGDFFSY 180 TRHEPVGVCG 190 QIIPWNFPLL 200 MQAWKLGPAL 210 ATGNVVVMKV 220 AEQTPLTALY 230 VANLIKEAGF 240 PPGVVNIVPG 250 FGPTAGAAIA 260 SHEDVDKVAF 270 TGSTEIGRVI 280 QVAAGSSNLK 290 RVTLELGGKS 300 PNIIMSDADM 310 DWAVEQAHFA 320 LFFNQGQCCC 330 AGSRTFVQED 340 IYDEFVERSV 350 ARAKSRVVGN 360 PFDSKTEQGP 370 QVDETQFKKI 380 LGYINTGKQE 390 GAKLLCGGGI 400 AADRGYFIQP 410 TVFGDVQDGM 420 TIAKEEIFGP 430 VMQILKFKTI 440 EEVVGRANNS 450 TYGLAAAVFT 460 KDLDKANYLS 470 QALQAGTVWV 480 NCYDVFGAQS 490 PFGGYKMSGS 500 GRELGEYGLQ 510 AYTEVKTVTV KVPQKNS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0004029 aldehyde dehydrogenase (NAD+) activity
Molecular Function GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity
Molecular Function GO:0106435 carboxylesterase activity
Molecular Function GO:0009055 electron transfer activity
Molecular Function GO:0051287 NAD binding
Molecular Function GO:0008957 phenylacetaldehyde dehydrogenase (NAD+) activity
Biological Process GO:0006066 alcohol metabolic process
Biological Process GO:0046185 aldehyde catabolic process
Biological Process GO:0005975 carbohydrate metabolic process
Biological Process GO:0110095 cellular detoxification of aldehyde
Biological Process GO:0006068 ethanol catabolic process
Biological Process GO:0006067 ethanol metabolic process
Biological Process GO:0018937 nitroglycerin metabolic process
Biological Process GO:1903179 regulation of dopamine biosynthetic process
Biological Process GO:1905627 regulation of serotonin biosynthetic process
Cellular Component GO:0070062 extracellular exosome

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.