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Overview

Uniprot IDP05107
Protein NameIntegrin beta-2
Gene NameITGB2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
462 DRSLCHGKGFLECGI

Function

Integrin ITGAL:ITGB2 is a receptor for ICAM1, ICAM2 and ICAM3 (PubMed:1676048, PubMed:23775590, PubMed:38195629). Integrin ITGAL:ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Integrins ITGAM:ITGB2 and ITGAX:ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX:ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM:ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM:ITGB2 is also a receptor for factor X. Integrin ITGAD:ITGB2 is a receptor for ICAM3 and VCAM1 (PubMed:10438935, PubMed:8777714, PubMed:9841932). Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL:ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). Integrins ITGAX:ITGB2 functions as a receptor of the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis (PubMed:16985175). Integrins ITGAX:ITGB2 functions as a receptor of the neuron-specific adhesion molecule ICAM5 ensuring neuron cell-leukocyte adhesion (PubMed:10741396). Integrin ITGAL:ITGB2 functions as a receptor of ICAM1 by acting as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion (PubMed:38195629). Integrin ITGAM:ITGB2/MAC-1 complex functions as a signaling receptor for the ligand receptor ICAM1, ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124). Integrin ITGAL/ITGB2 that functions as a signaling receptor of ICAM2, ensuring leukocyte cell-cell adhesion on resting cells (PubMed:1676048)

Protein Sequence

10 MLGLRPPLLA 20 LVGLLSLGCV 30 LSQECTKFKV 40 SSCRECIESG 50 PGCTWCQKLN 60 FTGPGDPDSI 70 RCDTRPQLLM 80 RGCAADDIMD 90 PTSLAETQED 100 HNGGQKQLSP 110 QKVTLYLRPG 120 QAAAFNVTFR 130 RAKGYPIDLY 140 YLMDLSYSML 150 DDLRNVKKLG 160 GDLLRALNEI 170 TESGRIGFGS 180 FVDKTVLPFV 190 NTHPDKLRNP 200 CPNKEKECQP 210 PFAFRHVLKL 220 TNNSNQFQTE 230 VGKQLISGNL 240 DAPEGGLDAM 250 MQVAACPEEI 260 GWRNVTRLLV 270 FATDDGFHFA 280 GDGKLGAILT 290 PNDGRCHLED 300 NLYKRSNEFD 310 YPSVGQLAHK 320 LAENNIQPIF 330 AVTSRMVKTY 340 EKLTEIIPKS 350 AVGELSEDSS 360 NVVHLIKNAY 370 NKLSSRVFLD 380 HNALPDTLKV 390 TYDSFCSNGV 400 THRNQPRGDC 410 DGVQINVPIT 420 FQVKVTATEC 430 IQEQSFVIRA 440 LGFTDIVTVQ 450 VLPQCECRCR 460 DQSRDRSLCH 470 GKGFLECGIC 480 RCDTGYIGKN 490 CECQTQGRSS 500 QELEGSCRKD 510 NNSIICSGLG 520 DCVCGQCLCH 530 TSDVPGKLIY 540 GQYCECDTIN 550 CERYNGQVCG 560 GPGRGLCFCG 570 KCRCHPGFEG 580 SACQCERTTE 590 GCLNPRRVEC 600 SGRGRCRCNV 610 CECHSGYQLP 620 LCQECPGCPS 630 PCGKYISCAE 640 CLKFEKGPFG 650 KNCSAACPGL 660 QLSNNPVKGR 670 TCKERDSEGC 680 WVAYTLEQQD 690 GMDRYLIYVD 700 ESRECVAGPN 710 IAAIVGGTVA 720 GIVLIGILLL 730 VIWKALIHLS 740 DLREYRRFEK 750 EKLKSQWNND 760 NPLFKSATTT VMNPKFAES

Gene Ontology

Classification GO ID Description
Biological Process GO:0045123 cellular extravasation
Cellular Component GO:0009986 cell surface
Cellular Component GO:0009897 external side of plasma membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:1903561 extracellular vesicle
Cellular Component GO:0101003 ficolin-1-rich granule membrane
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0034690 integrin alphaD-beta2 complex
Cellular Component GO:0034687 integrin alphaL-beta2 complex
Cellular Component GO:0034688 integrin alphaM-beta2 complex
Cellular Component GO:0034689 integrin alphaX-beta2 complex
Cellular Component GO:0008305 integrin complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0044853 plasma membrane raft
Cellular Component GO:0043235 receptor complex
Cellular Component GO:0035579 specific granule membrane
Cellular Component GO:0070821 tertiary granule membrane
Molecular Function GO:0001540 amyloid-beta binding
Molecular Function GO:0050839 cell adhesion molecule binding
Molecular Function GO:0001851 complement component C3b binding
Molecular Function GO:0031072 heat shock protein binding
Molecular Function GO:0030369 ICAM-3 receptor activity
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0019901 protein kinase binding
Biological Process GO:0097242 amyloid-beta clearance
Biological Process GO:0006915 apoptotic process
Biological Process GO:0007155 cell adhesion
Biological Process GO:0033627 cell adhesion mediated by integrin
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0033631 cell-cell adhesion mediated by integrin
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0071404 cellular response to low-density lipoprotein particle stimulus
Biological Process GO:0035987 endodermal cell differentiation
Biological Process GO:0043542 endothelial cell migration
Biological Process GO:0034113 heterotypic cell-cell adhesion
Biological Process GO:0006954 inflammatory response
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0061756 leukocyte adhesion to vascular endothelial cell
Biological Process GO:0007159 leukocyte cell-cell adhesion
Biological Process GO:0002523 leukocyte migration involved in inflammatory response
Biological Process GO:0001774 microglial cell activation
Biological Process GO:0045963 negative regulation of dopamine metabolic process
Biological Process GO:0007158 neuron cell-cell adhesion
Biological Process GO:0030593 neutrophil chemotaxis
Biological Process GO:1990266 neutrophil migration
Biological Process GO:0006909 phagocytosis
Biological Process GO:0006911 phagocytosis, engulfment
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
Biological Process GO:0043315 positive regulation of neutrophil degranulation
Biological Process GO:0045429 positive regulation of nitric oxide biosynthetic process
Biological Process GO:0090314 positive regulation of protein targeting to membrane
Biological Process GO:0032930 positive regulation of superoxide anion generation
Biological Process GO:0043113 receptor clustering
Biological Process GO:0031623 receptor internalization
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0050730 regulation of peptidyl-tyrosine phosphorylation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.