Search Results

Overview

Uniprot ID	P05155
Protein Name	Plasma protease C1 inhibitor
Gene Name	SERPING1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
273	VAKNTNNKISRLLDS
316	RMEPFHFKNSVIKVP
402	LLTLPRIKVTTSQDM

Function

Serine protease inhibitor, which acrs as a regulator of the classical complement pathway (PubMed:10946292, PubMed:11527969, PubMed:3458172, PubMed:6416294). Forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases (PubMed:10946292, PubMed:3458172, PubMed:6416294). May also regulate blood coagulation, fibrinolysis and the generation of kinins (PubMed:8495195). Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein (PubMed:8495195)

Protein Sequence

10 MASRLTLLTL 20 LLLLLAGDRA 30 SSNPNATSSS 40 SQDPESLQDR 50 GEGKVATTVI 60 SKMLFVEPIL 70 EVSSLPTTNS 80 TTNSATKITA 90 NTTDEPTTQP 100 TTEPTTQPTI 110 QPTQPTTQLP 120 TDSPTQPTTG 130 SFCPGPVTLC 140 SDLESHSTEA 150 VLGDALVDFS 160 LKLYHAFSAM 170 KKVETNMAFS 180 PFSIASLLTQ 190 VLLGAGENTK 200 TNLESILSYP 210 KDFTCVHQAL 220 KGFTTKGVTS 230 VSQIFHSPDL 240 AIRDTFVNAS 250 RTLYSSSPRV 260 LSNNSDANLE 270 LINTWVAKNT 280 NNKISRLLDS 290 LPSDTRLVLL 300 NAIYLSAKWK 310 TTFDPKKTRM 320 EPFHFKNSVI 330 KVPMMNSKKY 340 PVAHFIDQTL 350 KAKVGQLQLS 360 HNLSLVILVP 370 QNLKHRLEDM 380 EQALSPSVFK 390 AIMEKLEMSK 400 FQPTLLTLPR 410 IKVTTSQDML 420 SIMEKLEFFD 430 FSYDLNLCGL 440 TEDPDLQVSA 450 MQHQTVLELT 460 ETGVEAAAAS 470 AISVARTLLV 480 FEVQQPFLFV 490 LWDQQHKFPV 500 FMGRVYDPRA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0072562	blood microparticle
Cellular Component	GO:0005788	endoplasmic reticulum lumen
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0031012	extracellular matrix
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0031093	platelet alpha granule lumen
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity
Biological Process	GO:0008015	blood circulation
Biological Process	GO:0007596	blood coagulation
Biological Process	GO:0042730	fibrinolysis
Biological Process	GO:0001869	negative regulation of complement activation, lectin pathway

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.