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Overview

Uniprot IDP05181
Protein NameCytochrome P450 2E1
Gene NameCYP2E1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
140 LRNYGMGKQGNESRI
187 IADILFRKHFDYNDE
243 IKNVAEVKEYVSERV
84 MVVMHGYKAVKEALL
87 MHGYKAVKEALLDYK
94 KEALLDYKDEFSGRG

Function

A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable)

Protein Sequence

10 MSALGVTVAL 20 LVWAAFLLLV 30 SMWRQVHSSW 40 NLPPGPFPLP 50 IIGNLFQLEL 60 KNIPKSFTRL 70 AQRFGPVFTL 80 YVGSQRMVVM 90 HGYKAVKEAL 100 LDYKDEFSGR 110 GDLPAFHAHR 120 DRGIIFNNGP 130 TWKDIRRFSL 140 TTLRNYGMGK 150 QGNESRIQRE 160 AHFLLEALRK 170 TQGQPFDPTF 180 LIGCAPCNVI 190 ADILFRKHFD 200 YNDEKFLRLM 210 YLFNENFHLL 220 STPWLQLYNN 230 FPSFLHYLPG 240 SHRKVIKNVA 250 EVKEYVSERV 260 KEHHQSLDPN 270 CPRDLTDCLL 280 VEMEKEKHSA 290 ERLYTMDGIT 300 VTVADLFFAG 310 TETTSTTLRY 320 GLLILMKYPE 330 IEEKLHEEID 340 RVIGPSRIPA 350 IKDRQEMPYM 360 DAVVHEIQRF 370 ITLVPSNLPH 380 EATRDTIFRG 390 YLIPKGTVVV 400 PTLDSVLYDN 410 QEFPDPEKFK 420 PEHFLNENGK 430 FKYSDYFKPF 440 STGKRVCAGE 450 GLARMELFLL 460 LCAILQHFNL 470 KPLVDPKDID 480 LSPIHIGFGC 490 IPPRYKLCVI PRS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Biological Process GO:0001676 long-chain fatty acid metabolic process
Biological Process GO:0016098 monoterpenoid metabolic process
Biological Process GO:0008202 steroid metabolic process
Biological Process GO:0006805 xenobiotic metabolic process
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005743 mitochondrial inner membrane
Molecular Function GO:0018601 4-nitrophenol 2-monooxygenase activity
Molecular Function GO:0008392 arachidonate epoxygenase activity
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0020037 heme binding
Molecular Function GO:0030544 Hsp70 protein binding
Molecular Function GO:0051879 Hsp90 protein binding
Molecular Function GO:0005506 iron ion binding
Molecular Function GO:0120319 long-chain fatty acid omega-1 hydroxylase activity
Molecular Function GO:0004497 monooxygenase activity
Molecular Function GO:0016491 oxidoreductase activity
Molecular Function GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
Molecular Function GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Molecular Function GO:0019825 oxygen binding
Biological Process GO:0018960 4-nitrophenol metabolic process
Biological Process GO:0018910 benzene metabolic process
Biological Process GO:0018885 carbon tetrachloride metabolic process
Biological Process GO:0019373 epoxygenase P450 pathway
Biological Process GO:0042197 halogenated hydrocarbon metabolic process
Biological Process GO:0002933 lipid hydroxylation
Biological Process GO:0042759 long-chain fatty acid biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.