Overview
| Uniprot ID | P05362 |
|---|
| Protein Name | Intercellular adhesion molecule 1 |
|---|
| Gene Name | ICAM1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 67 |
IETPLPKKELLLPGN |
Function
Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength (PubMed:3086451, PubMed:3340213, PubMed:38195629). Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (PubMed:17875742). Promotes cell aggregation in epithelial cells through interaction with MUC1 (PubMed:11173916)
Protein Sequence
10
MAPSSPRPAL
20
PALLVLLGAL
30
FPGPGNAQTS
40
VSPSKVILPR
50
GGSVLVTCST
60
SCDQPKLLGI
70
ETPLPKKELL
80
LPGNNRKVYE
90
LSNVQEDSQP
100
MCYSNCPDGQ
110
STAKTFLTVY
120
WTPERVELAP
130
LPSWQPVGKN
140
LTLRCQVEGG
150
APRANLTVVL
160
LRGEKELKRE
170
PAVGEPAEVT
180
TTVLVRRDHH
190
GANFSCRTEL
200
DLRPQGLELF
210
ENTSAPYQLQ
220
TFVLPATPPQ
230
LVSPRVLEVD
240
TQGTVVCSLD
250
GLFPVSEAQV
260
HLALGDQRLN
270
PTVTYGNDSF
280
SAKASVSVTA
290
EDEGTQRLTC
300
AVILGNQSQE
310
TLQTVTIYSF
320
PAPNVILTKP
330
EVSEGTEVTV
340
KCEAHPRAKV
350
TLNGVPAQPL
360
GPRAQLLLKA
370
TPEDNGRSFS
380
CSATLEVAGQ
390
LIHKNQTREL
400
RVLYGPRLDE
410
RDCPGNWTWP
420
ENSQQTPMCQ
430
AWGNPLPELK
440
CLKDGTFPLP
450
IGESVTVTRD
460
LEGTYLCRAR
470
STQGEVTRKV
480
TVNVLSPRYE
490
IVIITVVAAA
500
VIMGTAGLST
510
YLYNRQRKIK
520
KYRLQQAQKG
530
TPMKPNTQAT
PP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0009897 |
external side of plasma membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0031012 |
extracellular matrix |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0001772 |
immunological synapse |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0045121 |
membrane raft |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005178 |
integrin binding |
| Molecular Function |
GO:0048018 |
receptor ligand activity |
| Molecular Function |
GO:0038023 |
signaling receptor activity |
| Molecular Function |
GO:0004888 |
transmembrane signaling receptor activity |
| Molecular Function |
GO:0001618 |
virus receptor activity |
| Biological Process |
GO:0044406 |
adhesion of symbiont to host |
| Biological Process |
GO:0007155 |
cell adhesion |
| Biological Process |
GO:0033631 |
cell-cell adhesion mediated by integrin |
| Biological Process |
GO:1904646 |
cellular response to amyloid-beta |
| Biological Process |
GO:0061028 |
establishment of endothelial barrier |
| Biological Process |
GO:0007157 |
heterophilic cell-cell adhesion |
| Biological Process |
GO:0061756 |
leukocyte adhesion to vascular endothelial cell |
| Biological Process |
GO:0007159 |
leukocyte cell-cell adhesion |
| Biological Process |
GO:0050900 |
leukocyte migration |
| Biological Process |
GO:0022614 |
membrane to membrane docking |
| Biological Process |
GO:2000352 |
negative regulation of endothelial cell apoptotic process |
| Biological Process |
GO:1902042 |
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| Biological Process |
GO:0002693 |
positive regulation of cellular extravasation |
| Biological Process |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
| Biological Process |
GO:0046813 |
receptor-mediated virion attachment to host cell |
| Biological Process |
GO:0001910 |
regulation of leukocyte mediated cytotoxicity |
| Biological Process |
GO:0002291 |
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.