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Overview

Uniprot IDP05388
Protein NameLarge ribosomal subunit protein uL10
Gene NameRPLP0
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
10 REDRATWKSNYFLKI
106 RDMLLANKVPAAARA
26 QLLDDYPKCFIVGAD
50 IRMSLRGKAVVLMGK
77 ENNPALEKLLPHIRG

Function

Ribosomal protein P0 is the functional equivalent of E.coli protein L10

Protein Sequence

10 MPREDRATWK 20 SNYFLKIIQL 30 LDDYPKCFIV 40 GADNVGSKQM 50 QQIRMSLRGK 60 AVVLMGKNTM 70 MRKAIRGHLE 80 NNPALEKLLP 90 HIRGNVGFVF 100 TKEDLTEIRD 110 MLLANKVPAA 120 ARAGAIAPCE 130 VTVPAQNTGL 140 GPEKTSFFQA 150 LGITTKISRG 160 TIEILSDVQL 170 IKTGDKVGAS 180 EATLLNMLNI 190 SPFSFGLVIQ 200 QVFDNGSIYN 210 PEVLDITEET 220 LHSRFLEGVR 230 NVASVCLQIG 240 YPTVASVPHS 250 IINGYKRVLA 260 LSVETDYTFP 270 LAEKVKAFLA 280 DPSAFVAAAP 290 VAAATTAAPA 300 AAAAPAKVEA 310 KEESEESDED MGFGLFD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0036464 cytoplasmic ribonucleoprotein granule
Cellular Component GO:0005829 cytosol
Cellular Component GO:0022625 cytosolic large ribosomal subunit
Cellular Component GO:0022626 cytosolic ribosome
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:1990904 ribonucleoprotein complex
Molecular Function GO:0070180 large ribosomal subunit rRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003735 structural constituent of ribosome
Biological Process GO:0002181 cytoplasmic translation
Biological Process GO:1901740 negative regulation of myoblast fusion
Biological Process GO:0042254 ribosome biogenesis
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0006941 striated muscle contraction
Biological Process GO:0006412 translation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.