Search Results
Overview
| Uniprot ID | P05412 |
|---|---|
| Protein Name | Transcription factor Jun |
| Gene Name | JUN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 268 | RNRIAASKCRKRKLE |
| 56 | LKPHLRAKNSDLLTS |
Function
Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306)
Protein Sequence
10
MTAKMETTFY
20
DDALNASFLP
30
SESGPYGYSN
40
PKILKQSMTL
50
NLADPVGSLK
60
PHLRAKNSDL
70
LTSPDVGLLK
80
LASPELERLI
90
IQSSNGHITT
100
TPTPTQFLCP
110
KNVTDEQEGF
120
AEGFVRALAE
130
LHSQNTLPSV
140
TSAAQPVNGA
150
GMVAPAVASV
160
AGGSGSGGFS
170
ASLHSEPPVY
180
ANLSNFNPGA
190
LSSGGGAPSY
200
GAAGLAFPAQ
210
PQQQQQPPHH
220
LPQQMPVQHP
230
RLQALKEEPQ
240
TVPEMPGETP
250
PLSPIDMESQ
260
ERIKAERKRM
270
RNRIAASKCR
280
KRKLERIARL
290
EEKVKTLKAQ
300
NSELASTANM
310
LREQVAQLKQ
320
KVMNHVNSGC
330
QLMLTQQLQT
F
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0000791 | euchromatin |
| Cellular Component | GO:0000228 | nuclear chromosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0035976 | transcription factor AP-1 complex |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Cellular Component | GO:0017053 | transcription repressor complex |
| Molecular Function | GO:0035497 | cAMP response element binding |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0140296 | general transcription initiation factor binding |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0070412 | R-SMAD binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Molecular Function | GO:0044389 | ubiquitin-like protein ligase binding |
| Biological Process | GO:0072740 | cellular response to anisomycin |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0043923 | host-mediated activation of viral transcription |
| Biological Process | GO:0043922 | host-mediated suppression of viral transcription |
| Biological Process | GO:0140467 | integrated stress response signaling |
| Biological Process | GO:0007254 | JNK cascade |
| Biological Process | GO:0043392 | negative regulation of DNA binding |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:2000144 | positive regulation of DNA-templated transcription initiation |
| Biological Process | GO:1902895 | positive regulation of miRNA transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:1904707 | positive regulation of vascular associated smooth muscle cell proliferation |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0042127 | regulation of cell population proliferation |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0019046 | release from viral latency |
| Biological Process | GO:0034976 | response to endoplasmic reticulum stress |
| Biological Process | GO:0048545 | response to steroid hormone |
| Biological Process | GO:0060395 | SMAD protein signal transduction |
| Biological Process | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:0032905 | transforming growth factor beta1 production |
Reference
PMID: N/A