Search Results
Overview
| Uniprot ID | P05413 |
|---|---|
| Protein Name | Fatty acid-binding protein, heart |
| Gene Name | FABP3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 59 | LKTHSTFKNTEISFK |
| 91 | IVTLDGGKLVHLQKW |
| 97 | GKLVHLQKWDGQETT |
Function
FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters
Protein Sequence
10
MVDAFLGTWK
20
LVDSKNFDDY
30
MKSLGVGFAT
40
RQVASMTKPT
50
TIIEKNGDIL
60
TLKTHSTFKN
70
TEISFKLGVE
80
FDETTADDRK
90
VKSIVTLDGG
100
KLVHLQKWDG
110
QETTLVRELI
120
DGKLILTLTH
130
GTAVCTRTYE
KEA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0016528 | sarcoplasm |
| Molecular Function | GO:0008092 | cytoskeletal protein binding |
| Molecular Function | GO:0050543 | icosatetraenoic acid binding |
| Molecular Function | GO:0005319 | lipid transporter activity |
| Molecular Function | GO:0036041 | long-chain fatty acid binding |
| Molecular Function | GO:0005324 | long-chain fatty acid transmembrane transporter activity |
| Molecular Function | GO:0070538 | oleic acid binding |
| Biological Process | GO:0042632 | cholesterol homeostasis |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0032365 | intracellular lipid transport |
| Biological Process | GO:0015909 | long-chain fatty acid transport |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0055091 | phospholipid homeostasis |
| Biological Process | GO:0140214 | positive regulation of long-chain fatty acid import into cell |
| Biological Process | GO:0071073 | positive regulation of phospholipid biosynthetic process |
| Biological Process | GO:0046320 | regulation of fatty acid oxidation |
| Biological Process | GO:0070542 | response to fatty acid |
| Biological Process | GO:0032868 | response to insulin |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0019433 | triglyceride catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.