Search Results
Overview
| Uniprot ID | P05546 |
|---|---|
| Protein Name | Heparin cofactor 2 |
| Gene Name | SERPIND1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 268 | KTNNHIMKLTKGLIK |
| 401 | LPKFKLEKNYNLVES |
Function
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner
Protein Sequence
10
MKHSLNALLI
20
FLIITSAWGG
30
SKGPLDQLEK
40
GGETAQSADP
50
QWEQLNNKNL
60
SMPLLPADFH
70
KENTVTNDWI
80
PEGEEDDDYL
90
DLEKIFSEDD
100
DYIDIVDSLS
110
VSPTDSDVSA
120
GNILQLFHGK
130
SRIQRLNILN
140
AKFAFNLYRV
150
LKDQVNTFDN
160
IFIAPVGIST
170
AMGMISLGLK
180
GETHEQVHSI
190
LHFKDFVNAS
200
SKYEITTIHN
210
LFRKLTHRLF
220
RRNFGYTLRS
230
VNDLYIQKQF
240
PILLDFKTKV
250
REYYFAEAQI
260
ADFSDPAFIS
270
KTNNHIMKLT
280
KGLIKDALEN
290
IDPATQMMIL
300
NCIYFKGSWV
310
NKFPVEMTHN
320
HNFRLNEREV
330
VKVSMMQTKG
340
NFLAANDQEL
350
DCDILQLEYV
360
GGISMLIVVP
370
HKMSGMKTLE
380
AQLTPRVVER
390
WQKSMTNRTR
400
EVLLPKFKLE
410
KNYNLVESLK
420
LMGIRMLFDK
430
NGNMAGISDQ
440
RIAIDLFKHQ
450
GTITVNEEGT
460
QATTVTTVGF
470
MPLSTQVRFT
480
VDRPFLFLIY
490
EHRTSCLLFM
GRVANPSRS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0004866 | endopeptidase inhibitor activity |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Biological Process | GO:0007596 | blood coagulation |
| Biological Process | GO:0006935 | chemotaxis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.