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Overview

Uniprot IDP05549
Protein NameTranscription factor AP-2-alpha
Gene NameTFAP2A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
177 PDQTVIKKGPVSLSK

Function

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They can also suppress a number of genes including MCAM/MUC18 and C/EBP alpha. Is involved in the negative regulation of Wnt canonical signaling, and is a transcriptional repressor of MYC (PubMed:33000225). AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region

Protein Sequence

10 MLWKLTDNIK 20 YEDCEDRHDG 30 TSNGTARLPQ 40 LGTVGQSPYT 50 SAPPLSHTPN 60 ADFQPPYFPP 70 PYQPIYPQSQ 80 DPYSHVNDPY 90 SLNPLHAQPQ 100 PQHPGWPGQR 110 QSQESGLLHT 120 HRGLPHQLSG 130 LDPRRDYRRH 140 EDLLHGPHAL 150 SSGLGDLSIH 160 SLPHAIEEVP 170 HVEDPGINIP 180 DQTVIKKGPV 190 SLSKSNSNAV 200 SAIPINKDNL 210 FGGVVNPNEV 220 FCSVPGRLSL 230 LSSTSKYKVT 240 VAEVQRRLSP 250 PECLNASLLG 260 GVLRRAKSKN 270 GGRSLREKLD 280 KIGLNLPAGR 290 RKAANVTLLT 300 SLVEGEAVHL 310 ARDFGYVCET 320 EFPAKAVAEF 330 LNRQHSDPNE 340 QVTRKNMLLA 350 TKQICKEFTD 360 LLAQDRSPLG 370 NSRPNPILEP 380 GIQSCLTHFN 390 LISHGFGSPA 400 VCAAVTALQN 410 YLTEALKAMD 420 KMYLSNNPNS 430 HTDNNAKSSD KEEKHRK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:2000378 negative regulation of reactive oxygen species metabolic process
Biological Process GO:0010944 negative regulation of transcription by competitive promoter binding
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0007399 nervous system development
Biological Process GO:0021623 oculomotor nerve formation
Biological Process GO:0003409 optic cup structural organization
Biological Process GO:0003404 optic vesicle morphogenesis
Biological Process GO:0030501 positive regulation of bone mineralization
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:0070172 positive regulation of tooth mineralization
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0045595 regulation of cell differentiation
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0010842 retina layer formation
Biological Process GO:0060021 roof of mouth development
Biological Process GO:0007605 sensory perception of sound
Biological Process GO:0001501 skeletal system development
Biological Process GO:0021559 trigeminal nerve development
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Biological Process GO:0060349 bone morphogenesis
Biological Process GO:0071281 cellular response to iron ion
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0048701 embryonic cranial skeleton morphogenesis
Biological Process GO:0035115 embryonic forelimb morphogenesis
Biological Process GO:0061029 eyelid development in camera-type eye
Biological Process GO:0042472 inner ear morphogenesis
Biological Process GO:0001822 kidney development
Biological Process GO:0043066 negative regulation of apoptotic process

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.