Search Results

Overview

Uniprot IDP05556
Protein NameIntegrin beta-1
Gene NameITGB1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
238 VFNELVGKQRISGNL
774 EKEKMNAKWDTGENP
794 VTTVVNPKYEGK***
93 SKDIKKNKNVTNRSK

Function

Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin FN1 and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity). ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similarity). Integrins ITGA9:ITGB1 and ITGA4:ITGB1 repress PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via their interaction with SVEP1, thereby inhibit vasocontraction (PubMed:35802072)

Protein Sequence

10 MNLQPIFWIG 20 LISSVCCVFA 30 QTDENRCLKA 40 NAKSCGECIQ 50 AGPNCGWCTN 60 STFLQEGMPT 70 SARCDDLEAL 80 KKKGCPPDDI 90 ENPRGSKDIK 100 KNKNVTNRSK 110 GTAEKLKPED 120 ITQIQPQQLV 130 LRLRSGEPQT 140 FTLKFKRAED 150 YPIDLYYLMD 160 LSYSMKDDLE 170 NVKSLGTDLM 180 NEMRRITSDF 190 RIGFGSFVEK 200 TVMPYISTTP 210 AKLRNPCTSE 220 QNCTSPFSYK 230 NVLSLTNKGE 240 VFNELVGKQR 250 ISGNLDSPEG 260 GFDAIMQVAV 270 CGSLIGWRNV 280 TRLLVFSTDA 290 GFHFAGDGKL 300 GGIVLPNDGQ 310 CHLENNMYTM 320 SHYYDYPSIA 330 HLVQKLSENN 340 IQTIFAVTEE 350 FQPVYKELKN 360 LIPKSAVGTL 370 SANSSNVIQL 380 IIDAYNSLSS 390 EVILENGKLS 400 EGVTISYKSY 410 CKNGVNGTGE 420 NGRKCSNISI 430 GDEVQFEISI 440 TSNKCPKKDS 450 DSFKIRPLGF 460 TEEVEVILQY 470 ICECECQSEG 480 IPESPKCHEG 490 NGTFECGACR 500 CNEGRVGRHC 510 ECSTDEVNSE 520 DMDAYCRKEN 530 SSEICSNNGE 540 CVCGQCVCRK 550 RDNTNEIYSG 560 KFCECDNFNC 570 DRSNGLICGG 580 NGVCKCRVCE 590 CNPNYTGSAC 600 DCSLDTSTCE 610 ASNGQICNGR 620 GICECGVCKC 630 TDPKFQGQTC 640 EMCQTCLGVC 650 AEHKECVQCR 660 AFNKGEKKDT 670 CTQECSYFNI 680 TKVESRDKLP 690 QPVQPDPVSH 700 CKEKDVDDCW 710 FYFTYSVNGN 720 NEVMVHVVEN 730 PECPTGPDII 740 PIVAGVVAGI 750 VLIGLALLLI 760 WKLLMIIHDR 770 REFAKFEKEK 780 MNAKWDTGEN 790 PIYKSAVTTV VNPKYEGK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009986 cell surface
Cellular Component GO:0150053 cerebellar climbing fiber to Purkinje cell synapse
Cellular Component GO:0032154 cleavage furrow
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0009897 external side of plasma membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0030175 filopodium
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0097386 glial cell projection
Cellular Component GO:0034665 integrin alpha1-beta1 complex
Cellular Component GO:0034680 integrin alpha10-beta1 complex
Cellular Component GO:0034681 integrin alpha11-beta1 complex
Cellular Component GO:0097060 synaptic membrane
Molecular Function GO:0003779 actin binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0050839 cell adhesion molecule binding
Molecular Function GO:0004895 cell adhesion receptor activity
Molecular Function GO:0098639 collagen binding involved in cell-matrix adhesion
Molecular Function GO:0015026 coreceptor activity
Molecular Function GO:0001968 fibronectin binding
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0098640 integrin binding involved in cell-matrix adhesion
Molecular Function GO:0043236 laminin binding
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0002020 protease binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:1990782 protein tyrosine kinase binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0001618 virus receptor activity
Biological Process GO:0001525 angiogenesis
Biological Process GO:0030183 B cell differentiation
Biological Process GO:0071711 basement membrane organization
Biological Process GO:0007161 calcium-independent cell-matrix adhesion
Biological Process GO:0023035 CD40 signaling pathway
Biological Process GO:0007155 cell adhesion
Biological Process GO:0033627 cell adhesion mediated by integrin
Biological Process GO:0016477 cell migration
Biological Process GO:0030030 cell projection organization
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0033631 cell-cell adhesion mediated by integrin
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0031589 cell-substrate adhesion
Biological Process GO:0006968 cellular defense response
Biological Process GO:0071404 cellular response to low-density lipoprotein particle stimulus
Biological Process GO:0000132 establishment of mitotic spindle orientation
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0034113 heterotypic cell-cell adhesion
Biological Process GO:0007156 homophilic cell-cell adhesion
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0030032 lamellipodium assembly
Biological Process GO:0007159 leukocyte cell-cell adhesion
Biological Process GO:0050901 leukocyte tethering or rolling
Biological Process GO:0035633 maintenance of blood-brain barrier
Biological Process GO:0048333 mesodermal cell differentiation
Biological Process GO:0007517 muscle organ development
Biological Process GO:0045445 myoblast differentiation
Biological Process GO:0007520 myoblast fusion
Biological Process GO:2000811 negative regulation of anoikis
Biological Process GO:0045906 negative regulation of vasoconstriction
Biological Process GO:0006909 phagocytosis
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
Biological Process GO:0010763 positive regulation of fibroblast migration
Biological Process GO:0051951 positive regulation of glutamate uptake involved in transmission of nerve impulse
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway
Biological Process GO:0090303 positive regulation of wound healing
Biological Process GO:0150103 reactive gliosis
Biological Process GO:0031623 receptor internalization
Biological Process GO:0010710 regulation of collagen catabolic process
Biological Process GO:0150003 regulation of spontaneous synaptic transmission
Biological Process GO:1905806 regulation of synapse pruning
Biological Process GO:0014850 response to muscle activity
Biological Process GO:0035313 wound healing, spreading of epidermal cells
Cellular Component GO:0034666 integrin alpha2-beta1 complex
Cellular Component GO:0034667 integrin alpha3-beta1 complex
Cellular Component GO:0034668 integrin alpha4-beta1 complex
Cellular Component GO:0034674 integrin alpha5-beta1 complex
Cellular Component GO:0034677 integrin alpha7-beta1 complex
Cellular Component GO:0034678 integrin alpha8-beta1 complex
Cellular Component GO:0034679 integrin alpha9-beta1 complex
Cellular Component GO:0008305 integrin complex
Cellular Component GO:0014704 intercalated disc
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0042470 melanosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0035748 myelin sheath abaxonal region
Cellular Component GO:0031594 neuromuscular junction
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0043235 receptor complex
Cellular Component GO:0055037 recycling endosome
Cellular Component GO:0001726 ruffle
Cellular Component GO:0032587 ruffle membrane
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Cellular Component GO:0045202 synapse

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.