Search Results

Overview

Uniprot IDP05787
Protein NameKeratin, type II cytoskeletal 8
Gene NameKRT8
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
101 QIKTLNNKFASFIDK
108 KFASFIDKVRFLEQQ
11 RVTQKSYKVSTSGPR
117 RFLEQQNKMLETKWS
122 QNKMLETKWSLLQQQ
130 WSLLQQQKTARSNMD
158 LETLGQEKLKLEAEL
160 TLGQEKLKLEAELGN
178 LVEDFKNKYEDEINK
185 KYEDEINKRTEMENE
197 ENEFVLIKKDVDEAY
198 NEFVLIKKDVDEAYM
207 VDEAYMNKVELESRL
295 ELQSLAGKHGDDLRR
304 GDDLRRTKTEISEMN
325 QAEIEGLKGQRASLE
347 QRGELAIKDANAKLS
352 AIKDANAKLSELEAA
393 IEIATYRKLLEGEES
465 SRAVVVKKIETRDGK
472 KIETRDGKLVSESSD

Function

Structural component of intermediate filaments in simple epithelial cells. Together with its obligate type I partner KRT18, contributes to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to epithelial cells (PubMed:26823019). Also involved in maintaining epithelial integrity and protecting cells from non-mechanical stress, such as apoptosis (By similarity). Also required for ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement (PubMed:26823019). In striated muscle, together with KRT19, may contribute to linking the contractile apparatus to dystrophin at the costameres (PubMed:16000376)

Protein Sequence

10 MSIRVTQKSY 20 KVSTSGPRAF 30 SSRSYTSGPG 40 SRISSSSFSR 50 VGSSNFRGGL 60 GGGYGGASGM 70 GGITAVTVNQ 80 SLLSPLVLEV 90 DPNIQAVRTQ 100 EKEQIKTLNN 110 KFASFIDKVR 120 FLEQQNKMLE 130 TKWSLLQQQK 140 TARSNMDNMF 150 ESYINNLRRQ 160 LETLGQEKLK 170 LEAELGNMQG 180 LVEDFKNKYE 190 DEINKRTEME 200 NEFVLIKKDV 210 DEAYMNKVEL 220 ESRLEGLTDE 230 INFLRQLYEE 240 EIRELQSQIS 250 DTSVVLSMDN 260 SRSLDMDSII 270 AEVKAQYEDI 280 ANRSRAEAES 290 MYQIKYEELQ 300 SLAGKHGDDL 310 RRTKTEISEM 320 NRNISRLQAE 330 IEGLKGQRAS 340 LEAAIADAEQ 350 RGELAIKDAN 360 AKLSELEAAL 370 QRAKQDMARQ 380 LREYQELMNV 390 KLALDIEIAT 400 YRKLLEGEES 410 RLESGMQNMS 420 IHTKTTSGYA 430 GGLSSAYGGL 440 TSPGLSYSLG 450 SSFGSGAGSS 460 SFSRTSSSRA 470 VVVKKIETRD 480 GKLVSESSDV LPK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016327 apicolateral plasma membrane
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005882 intermediate filament
Cellular Component GO:0045111 intermediate filament cytoskeleton
Cellular Component GO:0045095 keratin filament
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0030018 Z disc
Molecular Function GO:0097110 scaffold protein binding
Biological Process GO:0045214 sarcomere organization

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.