Overview
| Uniprot ID | P05942 |
|---|
| Protein Name | Protein S100-A4 |
|---|
| Gene Name | S100a4 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 26 |
YSGNEGDKFKLNKTE |
| 31 |
GDKFKLNKTELKELL |
| 35 |
KLNKTELKELLTREL |
| 57 |
TDEAAFQKLMNNLDS |
Function
Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (By similarity). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (By similarity). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (By similarity)
Protein Sequence
10
MARPLEEALD
20
VIVSTFHKYS
30
GNEGDKFKLN
40
KTELKELLTR
50
ELPSFLGRRT
60
DEAAFQKLMN
70
NLDSNRDNEV
80
DFQEYCVFLS
90
CIAMMCNEFF
100
EGCPDKEPRK
K
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Molecular Function |
GO:0003779 |
actin binding |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0048306 |
calcium-dependent protein binding |
| Molecular Function |
GO:0042056 |
chemoattractant activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0044877 |
protein-containing complex binding |
| Molecular Function |
GO:0050786 |
RAGE receptor binding |
| Molecular Function |
GO:0046914 |
transition metal ion binding |
| Biological Process |
GO:0043123 |
positive regulation of canonical NF-kappaB signal transduction |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.