Search Results
Overview
| Uniprot ID | P05943 |
|---|---|
| Protein Name | Protein S100-A10 |
| Gene Name | S100a10 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 23 | FHRFAGEKNYLTKED |
| 28 | GEKNYLTKEDLRVLM |
| 47 | PGFLENQKDPLAVDK |
| 54 | KDPLAVDKIMKDLDQ |
| 57 | LAVDKIMKDLDQCRD |
Function
Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase
Protein Sequence
10
MPSQMEHAME
20
TMMLTFHRFA
30
GEKNYLTKED
40
LRVLMEREFP
50
GFLENQKDPL
60
AVDKIMKDLD
70
QCRDGKVGFQ
80
SFLSLVAGLI
90
IACNDYFVVH
MKQKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1990665 | AnxA2-p11 complex |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098797 | plasma membrane protein complex |
| Cellular Component | GO:0090575 | RNA polymerase II transcription regulator complex |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0001765 | membrane raft assembly |
| Biological Process | GO:0042789 | mRNA transcription by RNA polymerase II |
| Biological Process | GO:0051894 | positive regulation of focal adhesion assembly |
| Biological Process | GO:0043547 | positive regulation of GTPase activity |
| Biological Process | GO:0010756 | positive regulation of plasminogen activation |
| Biological Process | GO:0051496 | positive regulation of stress fiber assembly |
| Biological Process | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0045595 | regulation of cell differentiation |
| Biological Process | GO:0001558 | regulation of cell growth |
| Biological Process | GO:0050767 | regulation of neurogenesis |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0006900 | vesicle budding from membrane |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.