Search Results
Overview
| Uniprot ID | P05964 |
|---|---|
| Protein Name | Protein S100-A6 |
| Gene Name | S100a6 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 26 | YSGKEGDKHTLSKKE |
| 35 | TLSKKELKELIQKEL |
| 40 | ELKELIQKELTIGAK |
| 47 | KELTIGAKLQDAEIA |
Function
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity)
Protein Sequence
10
MACPLDQAIG
20
LLVAIFHKYS
30
GKEGDKHTLS
40
KKELKELIQK
50
ELTIGAKLQD
60
AEIARLMDDL
70
DRNKDQEVNF
80
QEYVAFLGAL
ALIYNEALK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0001726 | ruffle |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0015075 | monoatomic ion transmembrane transporter activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0044548 | S100 protein binding |
| Molecular Function | GO:0005523 | tropomyosin binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0098586 | cellular response to virus |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.