Search Results

Overview

Uniprot ID	P06133
Protein Name	UDP-glucuronosyltransferase 2B4
Gene Name	UGT2B4
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
128	DILRKFCKDIVSNKK
134	CKDIVSNKKLMKKLQ
330	VIASALAKIPQKVLW
439	VINDPLYKENAMKLS
444	LYKENAMKLSRIHHD
455	IHHDQPVKPLDRAVF

Function

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867)

Protein Sequence

10 MSMKWTSALL 20 LIQLSCYFSS 30 GSCGKVLVWP 40 TEFSHWMNIK 50 TILDELVQRG 60 HEVTVLASSA 70 SISFDPNSPS 80 TLKFEVYPVS 90 LTKTEFEDII 100 KQLVKRWAEL 110 PKDTFWSYFS 120 QVQEIMWTFN 130 DILRKFCKDI 140 VSNKKLMKKL 150 QESRFDVVLA 160 DAVFPFGELL 170 AELLKIPFVY 180 SLRFSPGYAI 190 EKHSGGLLFP 200 PSYVPVVMSE 210 LSDQMTFIER 220 VKNMIYVLYF 230 EFWFQIFDMK 240 KWDQFYSEVL 250 GRPTTLSETM 260 AKADIWLIRN 270 YWDFQFPHPL 280 LPNVEFVGGL 290 HCKPAKPLPK 300 EMEEFVQSSG 310 ENGVVVFSLG 320 SMVSNTSEER 330 ANVIASALAK 340 IPQKVLWRFD 350 GNKPDTLGLN 360 TRLYKWIPQN 370 DLLGHPKTRA 380 FITHGGANGI 390 YEAIYHGIPM 400 VGVPLFADQP 410 DNIAHMKAKG 420 AAVSLDFHTM 430 SSTDLLNALK 440 TVINDPLYKE 450 NAMKLSRIHH 460 DQPVKPLDRA 470 VFWIEFVMRH 480 KGAKHLRVAA 490 HDLTWFQYHS 500 LDVTGFLLAC 510 VATVIFIITK 520 CLFCVWKFVR TGKKGKRD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Molecular Function	GO:0015020	glucuronosyltransferase activity
Biological Process	GO:0008210	estrogen metabolic process
Biological Process	GO:0006805	xenobiotic metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.