Search Results
Overview
| Uniprot ID | P06151 |
|---|---|
| Protein Name | L-lactate dehydrogenase A chain |
| Gene Name | Ldha |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 14 | QLIVNLLKEEQAPQN |
| 224 | ELGTDADKEQWKEVH |
| 228 | DADKEQWKEVHKQVV |
| 232 | EQWKEVHKQVVDSAY |
| 243 | DSAYEVIKLKGYTSW |
| 318 | EEEARLKKSADTLWG |
| 59 | DVMEDKLKGEMMDLQ |
Function
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)
Protein Sequence
10
MATLKDQLIV
20
NLLKEEQAPQ
30
NKITVVGVGA
40
VGMACAISIL
50
MKDLADELAL
60
VDVMEDKLKG
70
EMMDLQHGSL
80
FLKTPKIVSS
90
KDYCVTANSK
100
LVIITAGARQ
110
QEGESRLNLV
120
QRNVNIFKFI
130
IPNIVKYSPH
140
CKLLIVSNPV
150
DILTYVAWKI
160
SGFPKNRVIG
170
SGCNLDSARF
180
RYLMGERLGV
190
HALSCHGWVL
200
GEHGDSSVPV
210
WSGVNVAGVS
220
LKSLNPELGT
230
DADKEQWKEV
240
HKQVVDSAYE
250
VIKLKGYTSW
260
AIGLSVADLA
270
ESIMKNLRRV
280
HPISTMIKGL
290
YGINEDVFLS
300
VPCILGQNGI
310
SDVVKVTLTP
320
EEEARLKKSA
330
DTLWGIQKEL
QF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:1990204 | oxidoreductase complex |
| Cellular Component | GO:0035686 | sperm fibrous sheath |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0004459 | L-lactate dehydrogenase (NAD+) activity |
| Molecular Function | GO:0004457 | lactate dehydrogenase activity |
| Molecular Function | GO:0051287 | NAD binding |
| Biological Process | GO:0019661 | homolactic fermentation |
| Biological Process | GO:0019244 | lactate biosynthetic process from pyruvate |
| Biological Process | GO:0006089 | lactate metabolic process |
| Biological Process | GO:0042867 | pyruvate catabolic process |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.