Search Results
Overview
| Uniprot ID | P06396 |
|---|---|
| Protein Name | Gelsolin |
| Gene Name | GSN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 239 | SNRYERLKATQVSKG |
Function
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (PubMed:19666512). Plays a role in ciliogenesis (PubMed:20393563)
Protein Sequence
10
MAPHRPAPAL
20
LCALSLALCA
30
LSLPVRAATA
40
SRGASQAGAP
50
QGRVPEARPN
60
SMVVEHPEFL
70
KAGKEPGLQI
80
WRVEKFDLVP
90
VPTNLYGDFF
100
TGDAYVILKT
110
VQLRNGNLQY
120
DLHYWLGNEC
130
SQDESGAAAI
140
FTVQLDDYLN
150
GRAVQHREVQ
160
GFESATFLGY
170
FKSGLKYKKG
180
GVASGFKHVV
190
PNEVVVQRLF
200
QVKGRRVVRA
210
TEVPVSWESF
220
NNGDCFILDL
230
GNNIHQWCGS
240
NSNRYERLKA
250
TQVSKGIRDN
260
ERSGRARVHV
270
SEEGTEPEAM
280
LQVLGPKPAL
290
PAGTEDTAKE
300
DAANRKLAKL
310
YKVSNGAGTM
320
SVSLVADENP
330
FAQGALKSED
340
CFILDHGKDG
350
KIFVWKGKQA
360
NTEERKAALK
370
TASDFITKMD
380
YPKQTQVSVL
390
PEGGETPLFK
400
QFFKNWRDPD
410
QTDGLGLSYL
420
SSHIANVERV
430
PFDAATLHTS
440
TAMAAQHGMD
450
DDGTGQKQIW
460
RIEGSNKVPV
470
DPATYGQFYG
480
GDSYIILYNY
490
RHGGRQGQII
500
YNWQGAQSTQ
510
DEVAASAILT
520
AQLDEELGGT
530
PVQSRVVQGK
540
EPAHLMSLFG
550
GKPMIIYKGG
560
TSREGGQTAP
570
ASTRLFQVRA
580
NSAGATRAVE
590
VLPKAGALNS
600
NDAFVLKTPS
610
AAYLWVGTGA
620
SEAEKTGAQE
630
LLRVLRAQPV
640
QVAEGSEPDG
650
FWEALGGKAA
660
YRTSPRLKDK
670
KMDAHPPRLF
680
ACSNKIGRFV
690
IEEVPGELMQ
700
EDLATDDVML
710
LDTWDQVFVW
720
VGKDSQEEEK
730
TEALTSAKRY
740
IETDPANRDR
750
RTPITVVKQG
760
FEPPSFVGWF
770
LGWDDDYWSV
780
DPLDRAMAEL
AA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030478 | actin cap |
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0045335 | phagocytic vesicle |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0016528 | sarcoplasm |
| Cellular Component | GO:0034774 | secretory granule lumen |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0045159 | myosin II binding |
| Molecular Function | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Biological Process | GO:0051693 | actin filament capping |
| Biological Process | GO:0030042 | actin filament depolymerization |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0030041 | actin filament polymerization |
| Biological Process | GO:0051014 | actin filament severing |
| Biological Process | GO:0008154 | actin polymerization or depolymerization |
| Biological Process | GO:1990000 | amyloid fibril formation |
| Biological Process | GO:0051016 | barbed-end actin filament capping |
| Biological Process | GO:0086003 | cardiac muscle cell contraction |
| Biological Process | GO:0030031 | cell projection assembly |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0060271 | cilium assembly |
| Biological Process | GO:0097284 | hepatocyte apoptotic process |
| Biological Process | GO:0046597 | host-mediated suppression of symbiont invasion |
| Biological Process | GO:0006911 | phagocytosis, engulfment |
| Biological Process | GO:0051127 | positive regulation of actin nucleation |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:1902174 | positive regulation of keratinocyte apoptotic process |
| Biological Process | GO:1903923 | positive regulation of protein processing in phagocytic vesicle |
| Biological Process | GO:0031648 | protein destabilization |
| Biological Process | GO:1903903 | regulation of establishment of T cell polarity |
| Biological Process | GO:1903906 | regulation of plasma membrane raft polarization |
| Biological Process | GO:1903909 | regulation of receptor clustering |
| Biological Process | GO:0055119 | relaxation of cardiac muscle |
| Biological Process | GO:0097017 | renal protein absorption |
| Biological Process | GO:0035994 | response to muscle stretch |
| Biological Process | GO:0014891 | striated muscle atrophy |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.