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Overview

Uniprot IDP06401
Protein NameProgesterone receptor
Gene NamePGR
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
854 SYIRELIKAIGLRQK

Function

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor

Protein Sequence

10 MTELKAKGPR 20 APHVAGGPPS 30 PEVGSPLLCR 40 PAAGPFPGSQ 50 TSDTLPEVSA 60 IPISLDGLLF 70 PRPCQGQDPS 80 DEKTQDQQSL 90 SDVEGAYSRA 100 EATRGAGGSS 110 SSPPEKDSGL 120 LDSVLDTLLA 130 PSGPGQSQPS 140 PPACEVTSSW 150 CLFGPELPED 160 PPAAPATQRV 170 LSPLMSRSGC 180 KVGDSSGTAA 190 AHKVLPRGLS 200 PARQLLLPAS 210 ESPHWSGAPV 220 KPSPQAAAVE 230 VEEEDGSESE 240 ESAGPLLKGK 250 PRALGGAAAG 260 GGAAAVPPGA 270 AAGGVALVPK 280 EDSRFSAPRV 290 ALVEQDAPMA 300 PGRSPLATTV 310 MDFIHVPILP 320 LNHALLAART 330 RQLLEDESYD 340 GGAGAASAFA 350 PPRSSPCASS 360 TPVAVGDFPD 370 CAYPPDAEPK 380 DDAYPLYSDF 390 QPPALKIKEE 400 EEGAEASARS 410 PRSYLVAGAN 420 PAAFPDFPLG 430 PPPPLPPRAT 440 PSRPGEAAVT 450 AAPASASVSS 460 ASSSGSTLEC 470 ILYKAEGAPP 480 QQGPFAPPPC 490 KAPGASGCLL 500 PRDGLPSTSA 510 SAAAAGAAPA 520 LYPALGLNGL 530 PQLGYQAAVL 540 KEGLPQVYPP 550 YLNYLRPDSE 560 ASQSPQYSFE 570 SLPQKICLIC 580 GDEASGCHYG 590 VLTCGSCKVF 600 FKRAMEGQHN 610 YLCAGRNDCI 620 VDKIRRKNCP 630 ACRLRKCCQA 640 GMVLGGRKFK 650 KFNKVRVVRA 660 LDAVALPQPV 670 GVPNESQALS 680 QRFTFSPGQD 690 IQLIPPLINL 700 LMSIEPDVIY 710 AGHDNTKPDT 720 SSSLLTSLNQ 730 LGERQLLSVV 740 KWSKSLPGFR 750 NLHIDDQITL 760 IQYSWMSLMV 770 FGLGWRSYKH 780 VSGQMLYFAP 790 DLILNEQRMK 800 ESSFYSLCLT 810 MWQIPQEFVK 820 LQVSQEEFLC 830 MKVLLLLNTI 840 PLEGLRSQTQ 850 FEEMRSSYIR 860 ELIKAIGLRQ 870 KGVVSSSQRF 880 YQLTKLLDNL 890 HDLVKQLHLY 900 CLNTFIQSRA 910 LSVEFPEMMS 920 EVIAAQLPKI 930 LAGMVKPLLF HKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Molecular Function GO:0004879 nuclear receptor activity
Molecular Function GO:0003707 nuclear steroid receptor activity
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0005102 signaling receptor binding
Molecular Function GO:0005496 steroid binding
Molecular Function GO:0001223 transcription coactivator binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0051457 maintenance of protein location in nucleus
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0042326 negative regulation of phosphorylation
Biological Process GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0050847 progesterone receptor signaling pathway
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0007165 signal transduction
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0051117 ATPase binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0034056 estrogen response element binding
Molecular Function GO:0042802 identical protein binding

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.