Search Results

Overview

Uniprot IDP06454
Protein NameProthymosin alpha
Gene NamePTMA
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
103 EDDDVDTKKQKTDED
104 DDDVDTKKQKTDEDD
15 TSSEITTKDLKEKKE
18 EITTKDLKEKKEVVE
20 TTKDLKEKKEVVEEA
21 TKDLKEKKEVVEEAE

Function

Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections

Protein Sequence

10 MSDAAVDTSS 20 EITTKDLKEK 30 KEVVEEAENG 40 RDAPANGNAE 50 NEENGEQEAD 60 NEVDEEEEEG 70 GEEEEEEEEG 80 DGEEEDGDED 90 EEAESATGKR 100 AAEDDEDDDV 110 DTKKQKTDED D

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0140713 histone chaperone activity
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.