Search Results

Overview

Uniprot IDP06684
Protein NameComplement C5
Gene NameC5
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
858 NYMTSGTKFCVKMSA

Function

Precursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Activated downstream of classical, alternative, lectin and GZMK complement pathways

Protein Sequence

10 MGLWGILCLL 20 IFLDKTWGQE 30 QTYVISAPKI 40 LRVGSSENVV 50 IQVHGYTEAF 60 DATLSLKSYP 70 DKKVTFSSGY 80 VNLSPENKFQ 90 NAALLTLQPN 100 QVPREESPVS 110 HVYLEVVSKH 120 FSKSKKIPIT 130 YNNGILFIHT 140 DKPVYTPDQS 150 VKIRVYSLGD 160 DLKPAKRETV 170 LTFIDPEGSE 180 VDIVEENDYT 190 GIISFPDFKI 200 PSNPKYGVWT 210 IKANYKKDFT 220 TTGTAYFEIK 230 EYVLPRFSVS 240 IELERTFIGY 250 KNFKNFEITV 260 KARYFYNKVV 270 PDAEVYAFFG 280 LREDIKDEEK 290 QMMHKATQAA 300 KLVDGVAQIS 310 FDSETAVKEL 320 SYNSLEDLNN 330 KYLYIAVTVT 340 ESSGGFSEEA 350 EIPGVKYVLS 360 PYTLNLVATP 370 LFVKPGIPFS 380 IKAQVKDSLE 390 QAVGGVPVTL 400 MAQTVDVNQE 410 TSDLETKRSI 420 THDTDGVAVF 430 VLNLPSNVTV 440 LKFEIRTDDP 450 ELPEENQASK 460 EYEAVAYSSL 470 SQSYIYIAWT 480 ENYKPMLVGE 490 YLNIMVTPKS 500 PYIDKITHYN 510 YLILSKGKIV 520 QYGTREKLFS 530 STYQNINIPV 540 TQNMVPSARL 550 LVYYIVTGEQ 560 TAELVADAVW 570 INIEEKCGNQ 580 LQVHLSPDEY 590 VYSPGQTVSL 600 DMVTEADSWV 610 ALSAVDRAVY 620 KVQGNAKRAM 630 QRVFQALDEK 640 SDLGCGAGGG 650 HDNADVFHLA 660 GLTFLTNANA 670 DDSHYRDDSC 680 KEILRSKRNL 690 HLLRQKIEEQ 700 AAKYKHSVPK 710 KCCYDGARVN 720 FYETCEERVA 730 RVTIGPLCIR 740 AFNECCTIAN 750 KIRKESPHKP 760 VQLGRIHIKT 770 LLPVMKADIR 780 SYFPESWLWE 790 IHRVPKRKQL 800 QVTLPDSLTT 810 WEIQGIGISD 820 NGICVADTLK 830 AKVFKEVFLE 840 MNIPYSVVRG 850 EQIQLKGTVY 860 NYMTSGTKFC 870 VKMSAVEGIC 880 TSGSSAASLH 890 TSRPSRCVFQ 900 RIEGSSSHLV 910 TFTLLPLEIG 920 LHSINFSLET 930 SFGKDILVKT 940 LRVVPEGVKR 950 ESYAGVILDP 960 KGIRGIVNRR 970 KEFPYRIPLD 980 LVPKTKVERI 990 LSVKGLLVGE 1000 FLSTVLSKEG 1010 INILTHLPKG 1020 SAEAELMSIA 1030 PVFYVFHYLE 1040 AGNHWNIFYP 1050 DTLSKRQSLE 1060 KKIKQGVVSV 1070 MSYRNADYSY 1080 SMWKGASAST 1090 WLTAFALRVL 1100 GQVAKYVKQD 1110 ENSICNSLLW 1120 LVEKCQLENG 1130 SFKENSQYLP 1140 IKLQGTLPAE 1150 AQEKTLYLTA 1160 FSVIGIRKAV 1170 DICPTMKIHT 1180 ALDKADSFLL 1190 ENTLPSKSTF 1200 TLAIVAYALS 1210 LGDRTHPRFR 1220 LIVSALRKEA 1230 FVKGDPPIYR 1240 YWRDTLKRPD 1250 SSVPSSGTAG 1260 MVETTAYALL 1270 ASLKLKDMNY 1280 ANPIIKWLSE 1290 EQRYGGGFYS 1300 TQDTINAIEG 1310 LTEYSLLLKQ 1320 IHLDMDINVA 1330 YKHEGDFHKY 1340 KVTEKHFLGR 1350 PVEVSLNDDL 1360 VVSTGYSSGL 1370 ATVYVKTVVH 1380 KISVSEEFCS 1390 FYLKIDTQDI 1400 EASSHFRLSD 1410 SGFKRIIACA 1420 SYKPSKEEST 1430 SGSSHAVMDI 1440 SLPTGIGANE 1450 EDLRALVEGV 1460 DQLLTDYQIK 1470 DGHVILQLNS 1480 IPSRDFLCVR 1490 FRIFELFQVG 1500 FLNPATFTVY 1510 EYHRPDKQCT 1520 MIYSISDTRL 1530 QKVCEGAACT 1540 CVEADCAQLQ 1550 AEVDLAISAD 1560 SRKEKACKPE 1570 TAYAYKVRIT 1580 SATEENVFVK 1590 YTATLLVTYK 1600 TGEAADENSE 1610 VTFIKKMSCT 1620 NANLVKGKQY 1630 LIMGKEVLQI 1640 KHNFSFKYIY 1650 PLDSSTWIEY 1660 WPTDTTCPSC 1670 QAFVENLNNF 1680 AEDLFLNSCE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005579 membrane attack complex
Cellular Component GO:0044218 other organism cell membrane
Molecular Function GO:0004866 endopeptidase inhibitor activity
Biological Process GO:0006957 complement activation, alternative pathway
Biological Process GO:0006958 complement activation, classical pathway
Biological Process GO:0160257 complement activation, GZMK pathway
Biological Process GO:0001867 complement activation, lectin pathway
Biological Process GO:0006954 inflammatory response
Biological Process GO:0031640 killing of cells of another organism
Biological Process GO:0045766 positive regulation of angiogenesis

Reference

[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.