Search Results
Overview
| Uniprot ID | P06685 |
|---|---|
| Protein Name | Sodium/potassium-transporting ATPase subunit alpha-1 |
| Gene Name | Atp1a1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 156 | YQEAKSSKIMESFKN |
| 21 | AVSEHGDKKSKKAKK |
| 37 | RDMDELKKEVSMDDH |
| 377 | TSTICSDKTGTLTQN |
| 444 | QENLPILKRAVAGDA |
| 45 | EVSMDDHKLSLDELH |
| 476 | EMREKYTKIVEIPFN |
| 487 | IPFNSTNKYQLSIHK |
| 502 | NPNASEPKHLLVMKG |
| 508 | PKHLLVMKGAPERIL |
| 54 | SLDELHRKYGTDLSR |
| 605 | AVPDAVGKCRSAGIK |
| 612 | KCRSAGIKVIMVTGD |
| 625 | GDHPITAKAIAKGVG |
| 661 | QVNPRDAKACVVHGS |
| 698 | ARTSPQQKLIIVEGC |
| 727 | NDSPALKKADIGVAM |
| 773 | RLIFDNLKKSIAYTL |
| 843 | PRNPKTDKLVNERLI |
| 9 | GKGVGRDKYEPAAVS |
| 950 | SVFQQGMKNKILIFG |
Function
Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (PubMed:17939993, PubMed:30388404). This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity)
Protein Sequence
10
MGKGVGRDKY
20
EPAAVSEHGD
30
KKSKKAKKER
40
DMDELKKEVS
50
MDDHKLSLDE
60
LHRKYGTDLS
70
RGLTPARAAE
80
ILARDGPNAL
90
TPPPTTPEWV
100
KFCRQLFGGF
110
SMLLWIGAIL
120
CFLAYGIRSA
130
TEEEPPNDDL
140
YLGVVLSAVV
150
IITGCFSYYQ
160
EAKSSKIMES
170
FKNMVPQQAL
180
VIRNGEKMSI
190
NAEDVVVGDL
200
VEVKGGDRIP
210
ADLRIISANG
220
CKVDNSSLTG
230
ESEPQTRSPD
240
FTNENPLETR
250
NIAFFSTNCV
260
EGTARGIVVY
270
TGDRTVMGRI
280
ATLASGLEGG
290
QTPIAEEIEH
300
FIHLITGVAV
310
FLGVSFFILS
320
LILEYTWLEA
330
VIFLIGIIVA
340
NVPEGLLATV
350
TVCLTLTAKR
360
MARKNCLVKN
370
LEAVETLGST
380
STICSDKTGT
390
LTQNRMTVAH
400
MWFDNQIHEA
410
DTTENQSGVS
420
FDKTSATWFA
430
LSRIAGLCNR
440
AVFQANQENL
450
PILKRAVAGD
460
ASESALLKCI
470
EVCCGSVMEM
480
REKYTKIVEI
490
PFNSTNKYQL
500
SIHKNPNASE
510
PKHLLVMKGA
520
PERILDRCSS
530
ILLHGKEQPL
540
DEELKDAFQN
550
AYLELGGLGE
560
RVLGFCHLLL
570
PDEQFPEGFQ
580
FDTDEVNFPV
590
DNLCFVGLIS
600
MIDPPRAAVP
610
DAVGKCRSAG
620
IKVIMVTGDH
630
PITAKAIAKG
640
VGIISEGNET
650
VEDIAARLNI
660
PVNQVNPRDA
670
KACVVHGSDL
680
KDMTSEELDD
690
ILRYHTEIVF
700
ARTSPQQKLI
710
IVEGCQRQGA
720
IVAVTGDGVN
730
DSPALKKADI
740
GVAMGIVGSD
750
VSKQAADMIL
760
LDDNFASIVT
770
GVEEGRLIFD
780
NLKKSIAYTL
790
TSNIPEITPF
800
LIFIIANIPL
810
PLGTVTILCI
820
DLGTDMVPAI
830
SLAYEQAESD
840
IMKRQPRNPK
850
TDKLVNERLI
860
SMAYGQIGMI
870
QALGGFFTYF
880
VILAENGFLP
890
FHLLGIRETW
900
DDRWINDVED
910
SYGQQWTYEQ
920
RKIVEFTCHT
930
AFFVSIVVVQ
940
WADLVICKTR
950
RNSVFQQGMK
960
NKILIFGLFE
970
ETALAAFLSY
980
CPGMGAALRM
990
YPLKPTWWFC
1000
AFPYSLLIFV
1010
YDEVRKLIIR
1020
RRPGGWVEKE
TYY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0014704 | intercalated disc |
| Cellular Component | GO:0016328 | lateral plasma membrane |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0031090 | organelle membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0005890 | sodium:potassium-exchanging ATPase complex |
| Cellular Component | GO:0036126 | sperm flagellum |
| Cellular Component | GO:0030315 | T-tubule |
| Molecular Function | GO:0043531 | ADP binding |
| Molecular Function | GO:0030506 | ankyrin binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0008556 | P-type potassium transmembrane transporter activity |
| Molecular Function | GO:0005391 | P-type sodium:potassium-exchanging transporter activity |
| Molecular Function | GO:0016791 | phosphatase activity |
| Molecular Function | GO:0043548 | phosphatidylinositol 3-kinase binding |
| Molecular Function | GO:0030955 | potassium ion binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0031402 | sodium ion binding |
| Molecular Function | GO:1990239 | steroid hormone binding |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0060048 | cardiac muscle contraction |
| Biological Process | GO:0071260 | cellular response to mechanical stimulus |
| Biological Process | GO:0071383 | cellular response to steroid hormone stimulus |
| Biological Process | GO:0015988 | energy coupled proton transmembrane transport, against electrochemical gradient |
| Biological Process | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient |
| Biological Process | GO:0030007 | intracellular potassium ion homeostasis |
| Biological Process | GO:0006883 | intracellular sodium ion homeostasis |
| Biological Process | GO:0060081 | membrane hyperpolarization |
| Biological Process | GO:0086009 | membrane repolarization |
| Biological Process | GO:0031947 | negative regulation of glucocorticoid biosynthetic process |
| Biological Process | GO:0045822 | negative regulation of heart contraction |
| Biological Process | GO:0007231 | osmosensory signaling pathway |
| Biological Process | GO:0045823 | positive regulation of heart contraction |
| Biological Process | GO:0045989 | positive regulation of striated muscle contraction |
| Biological Process | GO:1990573 | potassium ion import across plasma membrane |
| Biological Process | GO:0071805 | potassium ion transmembrane transport |
| Biological Process | GO:0006813 | potassium ion transport |
| Biological Process | GO:1902600 | proton transmembrane transport |
| Biological Process | GO:0008217 | regulation of blood pressure |
| Biological Process | GO:0086004 | regulation of cardiac muscle cell contraction |
| Biological Process | GO:0002028 | regulation of sodium ion transport |
| Biological Process | GO:0002026 | regulation of the force of heart contraction |
| Biological Process | GO:0055119 | relaxation of cardiac muscle |
| Biological Process | GO:1903416 | response to glycoside |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0036376 | sodium ion export across plasma membrane |
| Biological Process | GO:0055078 | sodium ion homeostasis |
| Biological Process | GO:0035725 | sodium ion transmembrane transport |
| Biological Process | GO:0006814 | sodium ion transport |
| Biological Process | GO:0055085 | transmembrane transport |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.