Search Results
Overview
| Uniprot ID | P06687 |
|---|---|
| Protein Name | Sodium/potassium-transporting ATPase subunit alpha-3 |
| Gene Name | Atp1a3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1009 | NPGGWVEKETYY*** |
| 26 | RRDLDDLKKEVAMTE |
| 27 | RDLDDLKKEVAMTEH |
| 35 | EVAMTEHKMSVEEVC |
| 424 | LCNRAVFKGGQDNIP |
| 434 | QDNIPVLKRDVAGDA |
| 44 | SVEEVCRKYNTDCVQ |
| 458 | ELSSGSVKLMRERNK |
| 466 | LMRERNKKVAEIPFN |
| 498 | NRYLLVMKGAPERIL |
| 615 | GDHPITAKAIAKGVG |
| 651 | QVNPRDAKACVIHGT |
| 661 | VIHGTDLKDFTSEQI |
| 717 | NDSPALKKADIGVAM |
| 940 | SVFQQGMKNKILIFG |
Function
Neuron-specific alpha catalytic component of the Na(+)/K(+)-transporting ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed:2540801). Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze against their electrochemical gradients to maintain ion concentration gradients across the membranes. In the brain, ATP1A3 is critical for neuronal cell signaling and for maintenance of electrochemical stability, enabling cell excitation and action potential propagation (By similarity)
Protein Sequence
10
MGDKKDDKSS
20
PKKSKAKERR
30
DLDDLKKEVA
40
MTEHKMSVEE
50
VCRKYNTDCV
60
QGLTHSKAQE
70
ILARDGPNAL
80
TPPPTTPEWV
90
KFCRQLFGGF
100
SILLWIGAIL
110
CFLAYGIQAG
120
TEDDPSGDNL
130
YLGIVLAAVV
140
IITGCFSYYQ
150
EAKSSKIMES
160
FKNMVPQQAL
170
VIREGEKMQV
180
NAEEVVVGDL
190
VEIKGGDRVP
200
ADLRIISAHG
210
CKVDNSSLTG
220
ESEPQTRSPD
230
CTHDNPLETR
240
NITFFSTNCV
250
EGTARGVVVA
260
TGDRTVMGRI
270
ATLASGLEVG
280
KTPIAIEIEH
290
FIQLITGVAV
300
FLGVSFFILS
310
LILGYTWLEA
320
VIFLIGIIVA
330
NVPEGLLATV
340
TVCLTLTAKR
350
MARKNCLVKN
360
LEAVETLGST
370
STICSDKTGT
380
LTQNRMTVAH
390
MWFDNQIHEA
400
DTTEDQSGTS
410
FDKSSHTWVA
420
LSHIAGLCNR
430
AVFKGGQDNI
440
PVLKRDVAGD
450
ASESALLKCI
460
ELSSGSVKLM
470
RERNKKVAEI
480
PFNSTNKYQL
490
SIHETEDPND
500
NRYLLVMKGA
510
PERILDRCAT
520
ILLQGKEQPL
530
DEEMKEAFQN
540
AYLELGGLGE
550
RVLGFCHYYL
560
PEEQFPKGFA
570
FDCDDVNFTT
580
DNLCFVGLMS
590
MIDPPRAAVP
600
DAVGKCRSAG
610
IKVIMVTGDH
620
PITAKAIAKG
630
VGIISEGNET
640
VEDIAARLNI
650
PVSQVNPRDA
660
KACVIHGTDL
670
KDFTSEQIDE
680
ILQNHTEIVF
690
ARTSPQQKLI
700
IVEGCQRQGA
710
IVAVTGDGVN
720
DSPALKKADI
730
GVAMGIAGSD
740
VSKQAADMIL
750
LDDNFASIVT
760
GVEEGRLIFD
770
NLKKSIAYTL
780
TSNIPEITPF
790
LLFIMANIPL
800
PLGTITILCI
810
DLGTDMVPAI
820
SLAYEAAESD
830
IMKRQPRNPR
840
TDKLVNERLI
850
SMAYGQIGMI
860
QALGGFFSYF
870
VILAENGFLP
880
GNLVGIRLNW
890
DDRTVNDLED
900
SYGQQWTYEQ
910
RKVVEFTCHT
920
AFFVSIVVVQ
930
WADLIICKTR
940
RNSVFQQGMK
950
NKILIFGLFE
960
ETALAAFLSY
970
CPGMDVALRM
980
YPLKPSWWFC
990
AFPYSFLIFV
1000
YDEIRKLILR
1010
RNPGGWVEKE
TYY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0007623 | circadian rhythm |
| Biological Process | GO:0050890 | cognition |
| Biological Process | GO:0008340 | determination of adult lifespan |
| Biological Process | GO:0070371 | ERK1 and ERK2 cascade |
| Biological Process | GO:0042596 | fear response |
| Biological Process | GO:0007214 | gamma-aminobutyric acid signaling pathway |
| Biological Process | GO:0046959 | habituation |
| Biological Process | GO:0098977 | inhibitory chemical synaptic transmission |
| Biological Process | GO:0030007 | intracellular potassium ion homeostasis |
| Biological Process | GO:0006883 | intracellular sodium ion homeostasis |
| Biological Process | GO:0035235 | ionotropic glutamate receptor signaling pathway |
| Biological Process | GO:0019852 | L-ascorbic acid metabolic process |
| Biological Process | GO:0007612 | learning |
| Biological Process | GO:0040011 | locomotion |
| Biological Process | GO:0007626 | locomotory behavior |
| Biological Process | GO:0051899 | membrane depolarization |
| Biological Process | GO:0007613 | memory |
| Biological Process | GO:0061744 | motor behavior |
| Biological Process | GO:0035264 | multicellular organism growth |
| Biological Process | GO:0022008 | neurogenesis |
| Biological Process | GO:0050905 | neuromuscular process |
| Biological Process | GO:0050885 | neuromuscular process controlling balance |
| Biological Process | GO:1990535 | neuron projection maintenance |
| Biological Process | GO:0043491 | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0046931 | pore complex assembly |
| Biological Process | GO:1990573 | potassium ion import across plasma membrane |
| Biological Process | GO:0006813 | potassium ion transport |
| Biological Process | GO:1902600 | proton transmembrane transport |
| Biological Process | GO:0086036 | regulation of cardiac muscle cell membrane potential |
| Biological Process | GO:0048172 | regulation of short-term neuronal synaptic plasticity |
| Biological Process | GO:0014823 | response to activity |
| Biological Process | GO:0051602 | response to electrical stimulus |
| Biological Process | GO:0090648 | response to environmental enrichment |
| Biological Process | GO:0009725 | response to hormone |
| Biological Process | GO:0035902 | response to immobilization stress |
| Biological Process | GO:0010226 | response to lithium ion |
| Biological Process | GO:1904313 | response to methamphetamine hydrochloride |
| Biological Process | GO:0071867 | response to monoamine |
| Biological Process | GO:0035864 | response to potassium ion |
| Biological Process | GO:0006950 | response to stress |
| Biological Process | GO:0009266 | response to temperature stimulus |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0030431 | sleep |
| Biological Process | GO:0035176 | social behavior |
| Biological Process | GO:0036376 | sodium ion export across plasma membrane |
| Biological Process | GO:0006814 | sodium ion transport |
| Biological Process | GO:0021794 | thalamus development |
| Biological Process | GO:0019226 | transmission of nerve impulse |
| Biological Process | GO:0008542 | visual learning |
| Biological Process | GO:0090659 | walking behavior |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0044305 | calyx of Held |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0044327 | dendritic spine head |
| Cellular Component | GO:0044326 | dendritic spine neck |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0098984 | neuron to neuron synapse |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0031090 | organelle membrane |
| Cellular Component | GO:0001917 | photoreceptor inner segment |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0005890 | sodium:potassium-exchanging ATPase complex |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0031748 | D1 dopamine receptor binding |
| Molecular Function | GO:0043395 | heparan sulfate proteoglycan binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0005391 | P-type sodium:potassium-exchanging transporter activity |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Biological Process | GO:0008344 | adult locomotory behavior |
| Biological Process | GO:0008015 | blood circulation |
| Biological Process | GO:0031547 | brain-derived neurotrophic factor receptor signaling pathway |
| Biological Process | GO:0019722 | calcium-mediated signaling |
| Biological Process | GO:0046942 | carboxylic acid transport |
| Biological Process | GO:0060048 | cardiac muscle contraction |
| Biological Process | GO:1904646 | cellular response to amyloid-beta |
| Biological Process | GO:0071300 | cellular response to retinoic acid |
| Biological Process | GO:0097067 | cellular response to thyroid hormone stimulus |
| Biological Process | GO:0021987 | cerebral cortex development |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.