Search Results
Overview
| Uniprot ID | P06727 |
|---|---|
| Protein Name | Apolipoprotein A-IV |
| Gene Name | APOA4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 123 | HANEVSQKIGDNLRE |
| 187 | RPHADELKAKIDQNV |
| 189 | HADELKAKIDQNVEE |
| 198 | DQNVEELKGRLTPYA |
| 211 | YADEFKVKIDQTVEE |
| 253 | KKNAEELKARISASA |
| 287 | GNTEGLQKSLAELGG |
| 316 | PYGENFNKALVQQME |
| 350 | LEKDLRDKVNSFFST |
| 97 | RLAKDSEKLKEEIGK |
Function
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons
Protein Sequence
10
MFLKAVVLTL
20
ALVAVAGARA
30
EVSADQVATV
40
MWDYFSQLSN
50
NAKEAVEHLQ
60
KSELTQQLNA
70
LFQDKLGEVN
80
TYAGDLQKKL
90
VPFATELHER
100
LAKDSEKLKE
110
EIGKELEELR
120
ARLLPHANEV
130
SQKIGDNLRE
140
LQQRLEPYAD
150
QLRTQVSTQA
160
EQLRRQLTPY
170
AQRMERVLRE
180
NADSLQASLR
190
PHADELKAKI
200
DQNVEELKGR
210
LTPYADEFKV
220
KIDQTVEELR
230
RSLAPYAQDT
240
QEKLNHQLEG
250
LTFQMKKNAE
260
ELKARISASA
270
EELRQRLAPL
280
AEDVRGNLRG
290
NTEGLQKSLA
300
ELGGHLDQQV
310
EEFRRRVEPY
320
GENFNKALVQ
330
QMEQLRQKLG
340
PHAGDVEGHL
350
SFLEKDLRDK
360
VNSFFSTFKE
370
KESQDKTLSL
380
PELEQQQEQQ
390
QEQQQEQVQM
LAPLES
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0042627 | chylomicron |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1903561 | extracellular vesicle |
| Cellular Component | GO:0034364 | high-density lipoprotein particle |
| Cellular Component | GO:0034362 | low-density lipoprotein particle |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0034361 | very-low-density lipoprotein particle |
| Molecular Function | GO:0016209 | antioxidant activity |
| Molecular Function | GO:0120020 | cholesterol transfer activity |
| Molecular Function | GO:0005507 | copper ion binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0005319 | lipid transporter activity |
| Molecular Function | GO:0031210 | phosphatidylcholine binding |
| Molecular Function | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0055090 | acylglycerol homeostasis |
| Biological Process | GO:0033344 | cholesterol efflux |
| Biological Process | GO:0042632 | cholesterol homeostasis |
| Biological Process | GO:0008203 | cholesterol metabolic process |
| Biological Process | GO:0034378 | chylomicron assembly |
| Biological Process | GO:0034371 | chylomicron remodeling |
| Biological Process | GO:0034375 | high-density lipoprotein particle remodeling |
| Biological Process | GO:0042744 | hydrogen peroxide catabolic process |
| Biological Process | GO:0002227 | innate immune response in mucosa |
| Biological Process | GO:0007159 | leukocyte cell-cell adhesion |
| Biological Process | GO:0016042 | lipid catabolic process |
| Biological Process | GO:0055088 | lipid homeostasis |
| Biological Process | GO:0006869 | lipid transport |
| Biological Process | GO:0042157 | lipoprotein metabolic process |
| Biological Process | GO:0034445 | negative regulation of plasma lipoprotein oxidation |
| Biological Process | GO:0014012 | peripheral nervous system axon regeneration |
| Biological Process | GO:0046470 | phosphatidylcholine metabolic process |
| Biological Process | GO:0033700 | phospholipid efflux |
| Biological Process | GO:0045723 | positive regulation of fatty acid biosynthetic process |
| Biological Process | GO:0010898 | positive regulation of triglyceride catabolic process |
| Biological Process | GO:0065005 | protein-lipid complex assembly |
| Biological Process | GO:0032374 | regulation of cholesterol transport |
| Biological Process | GO:0019430 | removal of superoxide radicals |
| Biological Process | GO:0006982 | response to lipid hydroperoxide |
| Biological Process | GO:0035634 | response to stilbenoid |
| Biological Process | GO:0034014 | response to triglyceride |
| Biological Process | GO:0043691 | reverse cholesterol transport |
| Biological Process | GO:0034372 | very-low-density lipoprotein particle remodeling |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.