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Overview

Uniprot IDP06737
Protein NameGlycogen phosphorylase, liver form
Gene NamePYGL
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
10 KPLTDQEKRRQISIR
170 EYGIFNQKIRDGWQV
206 LPVHFYGKVEHTNTG
29 VENVAELKKSFNRHL
290 NDNFFEGKELRLKQE
3 *****MAKPLTDQEK
30 ENVAELKKSFNRHLH
316 IRRFKASKFGSTRGA
364 IEKLPWSKAWELTQK
410 IIYEINQKHLDRIVA
42 HLHFTLVKDRNVATT
421 RIVALFPKDVDRLRR
438 LIEEEGSKRINMAHL
465 KIHSDIVKTKVFKDF
470 IVKTKVFKDFSELEP
483 EPDKFQNKTNGITPR
521 KDLSQLTKLHSFLGD
545 VKQENKLKFSQFLET
555 QFLETEYKVKINPSS
557 LETEYKVKINPSSMF
609 RTVIIGGKAAPGYHM
618 APGYHMAKMIIKLIT
640 NDPMVGSKLKVIFLE
642 PMVGSKLKVIFLENY
724 DDVAALDKKGYEAKE
725 DVAALDKKGYEAKEY
730 DKKGYEAKEYYEALP
78 TQQHYYDKCPKRVYY
783 ADYEAYVKCQDKVSQ
804 AWNTMVLKNIAASGK
811 KNIAASGKFSSDRTI
819 FSSDRTIKEYAQNIW
843 SLSNESNKVNGN***

Function

Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis

Protein Sequence

10 MAKPLTDQEK 20 RRQISIRGIV 30 GVENVAELKK 40 SFNRHLHFTL 50 VKDRNVATTR 60 DYYFALAHTV 70 RDHLVGRWIR 80 TQQHYYDKCP 90 KRVYYLSLEF 100 YMGRTLQNTM 110 INLGLQNACD 120 EAIYQLGLDI 130 EELEEIEEDA 140 GLGNGGLGRL 150 AACFLDSMAT 160 LGLAAYGYGI 170 RYEYGIFNQK 180 IRDGWQVEEA 190 DDWLRYGNPW 200 EKSRPEFMLP 210 VHFYGKVEHT 220 NTGTKWIDTQ 230 VVLALPYDTP 240 VPGYMNNTVN 250 TMRLWSARAP 260 NDFNLRDFNV 270 GDYIQAVLDR 280 NLAENISRVL 290 YPNDNFFEGK 300 ELRLKQEYFV 310 VAATLQDIIR 320 RFKASKFGST 330 RGAGTVFDAF 340 PDQVAIQLND 350 THPALAIPEL 360 MRIFVDIEKL 370 PWSKAWELTQ 380 KTFAYTNHTV 390 LPEALERWPV 400 DLVEKLLPRH 410 LEIIYEINQK 420 HLDRIVALFP 430 KDVDRLRRMS 440 LIEEEGSKRI 450 NMAHLCIVGS 460 HAVNGVAKIH 470 SDIVKTKVFK 480 DFSELEPDKF 490 QNKTNGITPR 500 RWLLLCNPGL 510 AELIAEKIGE 520 DYVKDLSQLT 530 KLHSFLGDDV 540 FLRELAKVKQ 550 ENKLKFSQFL 560 ETEYKVKINP 570 SSMFDVQVKR 580 IHEYKRQLLN 590 CLHVITMYNR 600 IKKDPKKLFV 610 PRTVIIGGKA 620 APGYHMAKMI 630 IKLITSVADV 640 VNNDPMVGSK 650 LKVIFLENYR 660 VSLAEKVIPA 670 TDLSEQISTA 680 GTEASGTGNM 690 KFMLNGALTI 700 GTMDGANVEM 710 AEEAGEENLF 720 IFGMRIDDVA 730 ALDKKGYEAK 740 EYYEALPELK 750 LVIDQIDNGF 760 FSPKQPDLFK 770 DIINMLFYHD 780 RFKVFADYEA 790 YVKCQDKVSQ 800 LYMNPKAWNT 810 MVLKNIAASG 820 KFSSDRTIKE 830 YAQNIWNVEP 840 SDLKISLSNE SNKVNGN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0034774 secretory granule lumen
Molecular Function GO:0016208 AMP binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0032052 bile acid binding
Molecular Function GO:0005536 D-glucose binding
Molecular Function GO:0008184 glycogen phosphorylase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0002060 purine nucleobase binding
Molecular Function GO:0030170 pyridoxal phosphate binding
Molecular Function GO:0019842 vitamin binding
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0005980 glycogen catabolic process
Biological Process GO:0005977 glycogen metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.