Overview
| Uniprot ID | P06745 |
|---|
| Protein Name | Glucose-6-phosphate isomerase |
|---|
| Gene Name | Gpi |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 252 |
ALSTNTAKVKEFGID |
| 454 |
KELQAAGKSPEDLEK |
Function
Isomerase that catalyzes the conversion of alpha-D-glucose-6-phosphate to beta-D-fructose-6-phosphate, the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm (PubMed:2344351, PubMed:7277315, PubMed:8417789). Also shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) and D-mannose-6-phosphate (M6P) (By similarity). Also displays anomerase activity, interconverting alpha and beta-anomeric forms of G6P, D-fructose-6-phosphate and M6P (By similarity). In addition to its metabolic role, this enzyme functions extracellularly as a cytokine: acts as autocrine motility factor (AMF), a secreted angiogenic factor that enhances endothelial cell motility (By similarity). Functions as neuroleukin, a neurotrophic factor supporting the survival of spinal and sensory neurons (PubMed:3352745, PubMed:3764429). Released by lectin-stimulated T-cells to induce immunoglobulin secretion (PubMed:3352745)
Protein Sequence
10
MAALTRNPQF
20
QKLLEWHRAN
30
SANLKLRELF
40
EADPERFNNF
50
SLNLNTNHGH
60
ILVDYSKNLV
70
NKEVMQMLVE
80
LAKSRGVEAA
90
RDNMFSGSKI
100
NYTENRAVLH
110
VALRNRSNTP
120
IKVDGKDVMP
130
EVNRVLDKMK
140
SFCQRVRSGD
150
WKGYTGKSIT
160
DIINIGIGGS
170
DLGPLMVTEA
180
LKPYSKGGPR
190
VWFVSNIDGT
200
HIAKTLASLS
210
PETSLFIIAS
220
KTFTTQETIT
230
NAETAKEWFL
240
EAAKDPSAVA
250
KHFVALSTNT
260
AKVKEFGIDP
270
QNMFEFWDWV
280
GGRYSLWSAI
290
GLSIALHVGF
300
DHFEQLLSGA
310
HWMDQHFLKT
320
PLEKNAPVLL
330
ALLGIWYINC
340
YGCETHALLP
350
YDQYMHRFAA
360
YFQQGDMESN
370
GKYITKSGAR
380
VDHQTGPIVW
390
GEPGTNGQHA
400
FYQLIHQGTK
410
MIPCDFLIPV
420
QTQHPIRKGL
430
HHKILLANFL
440
AQTEALMKGK
450
LPEEARKELQ
460
AAGKSPEDLE
470
KLLPHKVFEG
480
NRPTNSIVFT
490
KLTPFILGAL
500
IAMYEHKIFV
510
QGIMWDINSF
520
DQWGVELGKQ
530
LAKKIEPELE
540
GSSAVTSHDS
550
STNGLISFIK
QQRDTKLE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0043209 |
myelin sheath |
| Molecular Function |
GO:0097367 |
carbohydrate derivative binding |
| Molecular Function |
GO:0005125 |
cytokine activity |
| Molecular Function |
GO:0047938 |
glucose-6-phosphate 1-epimerase activity |
| Molecular Function |
GO:0004347 |
glucose-6-phosphate isomerase activity |
| Molecular Function |
GO:0008083 |
growth factor activity |
| Molecular Function |
GO:0048029 |
monosaccharide binding |
| Molecular Function |
GO:0016857 |
racemase and epimerase activity, acting on carbohydrates and derivatives |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Biological Process |
GO:0006002 |
fructose 6-phosphate metabolic process |
| Biological Process |
GO:0006094 |
gluconeogenesis |
| Biological Process |
GO:0051156 |
glucose 6-phosphate metabolic process |
| Biological Process |
GO:0006096 |
glycolytic process |
| Biological Process |
GO:0007611 |
learning or memory |
| Biological Process |
GO:0043066 |
negative regulation of apoptotic process |
| Biological Process |
GO:0010595 |
positive regulation of endothelial cell migration |
| Biological Process |
GO:0002639 |
positive regulation of immunoglobulin production |
| Biological Process |
GO:0046686 |
response to cadmium ion |
| Biological Process |
GO:0032355 |
response to estradiol |
| Biological Process |
GO:0035902 |
response to immobilization stress |
| Biological Process |
GO:0035994 |
response to muscle stretch |
| Biological Process |
GO:0032570 |
response to progesterone |
| Biological Process |
GO:0033574 |
response to testosterone |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.