Search Results

Overview

Uniprot IDP06753
Protein NameTropomyosin alpha-3 chain
Gene NameTPM3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
169 KYEEVARKLVIIEGD
206 KNVTNNLKSLEAQAE
214 SLEAQAEKYSQKEDK
265 EDELYAQKLKYKAIS

Function

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments

Protein Sequence

10 MMEAIKKKMQ 20 MLKLDKENAL 30 DRAEQAEAEQ 40 KQAEERSKQL 50 EDELAAMQKK 60 LKGTEDELDK 70 YSEALKDAQE 80 KLELAEKKAA 90 DAEAEVASLN 100 RRIQLVEEEL 110 DRAQERLATA 120 LQKLEEAEKA 130 ADESERGMKV 140 IENRALKDEE 150 KMELQEIQLK 160 EAKHIAEEAD 170 RKYEEVARKL 180 VIIEGDLERT 190 EERAELAESK 200 CSELEEELKN 210 VTNNLKSLEA 220 QAEKYSQKED 230 KYEEEIKILT 240 DKLKEAETRA 250 EFAERSVAKL 260 EKTIDDLEDE 270 LYAQKLKYKA 280 ISEELDHALN DMTSI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005884 actin filament
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005862 muscle thin filament tropomyosin
Cellular Component GO:0001725 stress fiber
Molecular Function GO:0051015 actin filament binding
Biological Process GO:0007015 actin filament organization
Biological Process GO:0006936 muscle contraction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.