Search Results
Overview
| Uniprot ID | P07108 |
|---|---|
| Protein Name | Acyl-CoA-binding protein |
| Gene Name | DBI |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 17 | AEEVRHLKTKPSDEE |
| 19 | EVRHLKTKPSDEEML |
| 33 | LFIYGHYKQATVGDI |
| 53 | GMLDFTGKAKWDAWN |
| 55 | LDFTGKAKWDAWNEL |
| 63 | WDAWNELKGTSKEDA |
| 67 | NELKGTSKEDAMKAY |
| 72 | TSKEDAMKAYINKVE |
| 77 | AMKAYINKVEELKKK |
| 8 | MSQAEFEKAAEEVRH |
Function
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0097038 | perinuclear endoplasmic reticulum |
| Cellular Component | GO:0032994 | protein-lipid complex |
| Molecular Function | GO:0030156 | benzodiazepine receptor binding |
| Molecular Function | GO:0000062 | fatty-acyl-CoA binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0036042 | long-chain fatty acyl-CoA binding |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0036151 | phosphatidylcholine acyl-chain remodeling |
| Biological Process | GO:2001140 | positive regulation of phospholipid transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.