Search Results
Overview
| Uniprot ID | P07148 |
|---|---|
| Protein Name | Fatty acid-binding protein, liver |
| Gene Name | FABP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 121 | TLGDIVFKRISKRI* |
| 31 | LPEELIQKGKDIKGV |
| 33 | EELIQKGKDIKGVSE |
| 36 | IQKGKDIKGVSEIVQ |
| 46 | SEIVQNGKHFKFTIT |
| 49 | VQNGKHFKFTITAGS |
| 78 | LETMTGEKVKTVVQL |
| 80 | TMTGEKVKTVVQLEG |
| 90 | VQLEGDNKLVTTFKN |
| 96 | NKLVTTFKNIKSVTE |
Function
Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity)
Protein Sequence
10
MSFSGKYQLQ
20
SQENFEAFMK
30
AIGLPEELIQ
40
KGKDIKGVSE
50
IVQNGKHFKF
60
TITAGSKVIQ
70
NEFTVGEECE
80
LETMTGEKVK
90
TVVQLEGDNK
100
LVTTFKNIKS
110
VTELNGDIIT
120
NTMTLGDIVF
KRISKRI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005782 | peroxisomal matrix |
| Molecular Function | GO:0016209 | antioxidant activity |
| Molecular Function | GO:0015485 | cholesterol binding |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0005504 | fatty acid binding |
| Molecular Function | GO:0120013 | lipid transfer activity |
| Molecular Function | GO:0005319 | lipid transporter activity |
| Molecular Function | GO:0005324 | long-chain fatty acid transmembrane transporter activity |
| Molecular Function | GO:0036042 | long-chain fatty acyl-CoA binding |
| Molecular Function | GO:0140104 | molecular carrier activity |
| Biological Process | GO:1990748 | cellular detoxification |
| Biological Process | GO:0070301 | cellular response to hydrogen peroxide |
| Biological Process | GO:0071456 | cellular response to hypoxia |
| Biological Process | GO:0015908 | fatty acid transport |
| Biological Process | GO:0042167 | heme catabolic process |
| Biological Process | GO:0019216 | regulation of lipid metabolic process |
| Biological Process | GO:0019433 | triglyceride catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.