Search Results
Overview
| Uniprot ID | P07150 |
|---|---|
| Protein Name | Annexin A1 |
| Gene Name | Anxa1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 128 | DELRAAMKGLGTDED |
| 16 | KQACYIEKQEQEYVQ |
| 166 | ELKRDLAKDITSDTS |
| 185 | NALLALAKGDRCEDM |
| 214 | YEAGERRKGTDVNVF |
| 235 | RSYPHLRKVFQNYRK |
| 242 | KVFQNYRKYSQHDMN |
| 250 | YSQHDMNKALDLELK |
| 257 | KALDLELKGDIEKCL |
| 26 | QEYVQAVKSYKGGPG |
| 262 | ELKGDIEKCLTTIVK |
| 287 | EKLYEAMKGAGTRHK |
| 29 | VQAVKSYKGGPGSAV |
| 312 | EIDMNEIKVFYQKKY |
| 318 | IKVFYQKKYGIPLCQ |
| 53 | SDVAALHKAIMVKGV |
| 58 | LHKAIMVKGVDEATI |
| 71 | TIIDILTKRTNAQRQ |
| 81 | NAQRQQIKAAYLQET |
| 90 | AYLQETGKPLDETLK |
| 97 | KPLDETLKKALTGHL |
| 98 | PLDETLKKALTGHLE |
Function
Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T cells. Promotes the differentiation of T cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T cells. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:3020049). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). In the context of antitumor immunity, interacts with FPR1 on dendritic cells allowing for tumor-associated antigens uptake and cross-presentation to T cells to mount an antitumor specific T cell response
Protein Sequence
10
MAMVSEFLKQ
20
ACYIEKQEQE
30
YVQAVKSYKG
40
GPGSAVSPYP
50
SFNPSSDVAA
60
LHKAIMVKGV
70
DEATIIDILT
80
KRTNAQRQQI
90
KAAYLQETGK
100
PLDETLKKAL
110
TGHLEEVVLA
120
MLKTPAQFDA
130
DELRAAMKGL
140
GTDEDTLIEI
150
LTTRSNQQIR
160
EITRVYREEL
170
KRDLAKDITS
180
DTSGDFRNAL
190
LALAKGDRCE
200
DMSVNQDLAD
210
TDARALYEAG
220
ERRKGTDVNV
230
FNTILTTRSY
240
PHLRKVFQNY
250
RKYSQHDMNK
260
ALDLELKGDI
270
EKCLTTIVKC
280
ATSTPAFFAE
290
KLYEAMKGAG
300
TRHKTLIRIM
310
VSRSEIDMNE
320
IKVFYQKKYG
330
IPLCQAILDE
340
TKGDYEKILV
ALCGGN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis |
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0001533 | cornified envelope |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0016328 | lateral plasma membrane |
| Cellular Component | GO:0042629 | mast cell granule |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0031514 | motile cilium |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0001891 | phagocytic cup |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0097060 | synaptic membrane |
| Cellular Component | GO:0012506 | vesicle membrane |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005544 | calcium-dependent phospholipid binding |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:1990814 | DNA/DNA annealing activity |
| Molecular Function | GO:0036121 | double-stranded DNA helicase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0001786 | phosphatidylserine binding |
| Molecular Function | GO:0019834 | phospholipase A2 inhibitor activity |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0002250 | adaptive immune response |
| Biological Process | GO:0046632 | alpha-beta T cell differentiation |
| Biological Process | GO:0050482 | arachidonate secretion |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0071385 | cellular response to glucocorticoid stimulus |
| Biological Process | GO:0070301 | cellular response to hydrogen peroxide |
| Biological Process | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| Biological Process | GO:0031018 | endocrine pancreas development |
| Biological Process | GO:0044849 | estrous cycle |
| Biological Process | GO:0007187 | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| Biological Process | GO:0042063 | gliogenesis |
| Biological Process | GO:0071621 | granulocyte chemotaxis |
| Biological Process | GO:0070365 | hepatocyte differentiation |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0030073 | insulin secretion |
| Biological Process | GO:0030216 | keratinocyte differentiation |
| Biological Process | GO:0002548 | monocyte chemotaxis |
| Biological Process | GO:0014839 | myoblast migration involved in skeletal muscle regeneration |
| Biological Process | GO:0045920 | negative regulation of exocytosis |
| Biological Process | GO:0032717 | negative regulation of interleukin-8 production |
| Biological Process | GO:0050709 | negative regulation of protein secretion |
| Biological Process | GO:0045629 | negative regulation of T-helper 2 cell differentiation |
| Biological Process | GO:0042119 | neutrophil activation |
| Biological Process | GO:0097350 | neutrophil clearance |
| Biological Process | GO:0001780 | neutrophil homeostasis |
| Biological Process | GO:0018149 | peptide cross-linking |
| Biological Process | GO:0006909 | phagocytosis |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:0032743 | positive regulation of interleukin-2 production |
| Biological Process | GO:0033031 | positive regulation of neutrophil apoptotic process |
| Biological Process | GO:0031394 | positive regulation of prostaglandin biosynthetic process |
| Biological Process | GO:0042102 | positive regulation of T cell proliferation |
| Biological Process | GO:0045627 | positive regulation of T-helper 1 cell differentiation |
| Biological Process | GO:0031340 | positive regulation of vesicle fusion |
| Biological Process | GO:0090303 | positive regulation of wound healing |
| Biological Process | GO:0070459 | prolactin secretion |
| Biological Process | GO:0030850 | prostate gland development |
| Biological Process | GO:0042127 | regulation of cell population proliferation |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:0046883 | regulation of hormone secretion |
| Biological Process | GO:0050727 | regulation of inflammatory response |
| Biological Process | GO:0032652 | regulation of interleukin-1 production |
| Biological Process | GO:0002685 | regulation of leukocyte migration |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:0051384 | response to glucocorticoid |
| Biological Process | GO:0009725 | response to hormone |
| Biological Process | GO:0070555 | response to interleukin-1 |
| Biological Process | GO:1904373 | response to kainic acid |
| Biological Process | GO:0043434 | response to peptide hormone |
| Biological Process | GO:0010165 | response to X-ray |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.