Search Results

Overview

Uniprot IDP07195
Protein NameL-lactate dehydrogenase B chain
Gene NameLDHB
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
156 WKLSGLPKHRVIGSG
244 ESAYEVIKLKGYTNW
279 HPVSTMVKGMYGIEN
308 LTSVINQKLKDDEVA
310 SVINQKLKDDEVAQL
318 DDEVAQLKKSADTLW
319 DEVAQLKKSADTLWD
60 DVLEDKLKGEMMDLQ
7 *MATLKEKLIAPVAE
82 TPKIVADKDYSVTAN

Function

Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)

Protein Sequence

10 MATLKEKLIA 20 PVAEEEATVP 30 NNKITVVGVG 40 QVGMACAISI 50 LGKSLADELA 60 LVDVLEDKLK 70 GEMMDLQHGS 80 LFLQTPKIVA 90 DKDYSVTANS 100 KIVVVTAGVR 110 QQEGESRLNL 120 VQRNVNVFKF 130 IIPQIVKYSP 140 DCIIIVVSNP 150 VDILTYVTWK 160 LSGLPKHRVI 170 GSGCNLDSAR 180 FRYLMAEKLG 190 IHPSSCHGWI 200 LGEHGDSSVA 210 VWSGVNVAGV 220 SLQELNPEMG 230 TDNDSENWKE 240 VHKMVVESAY 250 EVIKLKGYTN 260 WAIGLSVADL 270 IESMLKNLSR 280 IHPVSTMVKG 290 MYGIENEVFL 300 SLPCILNARG 310 LTSVINQKLK 320 DDEVAQLKKS 330 ADTLWDIQKD LKDL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019900 kinase binding
Molecular Function GO:0004459 L-lactate dehydrogenase (NAD+) activity
Molecular Function GO:0051287 NAD binding
Biological Process GO:0006089 lactate metabolic process
Biological Process GO:0019674 NAD+ metabolic process
Biological Process GO:0042867 pyruvate catabolic process

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.