Search Results
Overview
| Uniprot ID | P07196 |
|---|---|
| Protein Name | Neurofilament light polypeptide |
| Gene Name | NEFL |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 116 | HELEQQNKVLEAELL |
| 157 | AEDATNEKQALQGER |
| 224 | MDEISFLKKVHEEEI |
| 267 | DIRAQYEKLAAKNMQ |
| 271 | QYEKLAAKNMQNAEE |
| 281 | QNAEEWFKSRFTVLT |
| 293 | VLTESAAKNTDAVRA |
| 315 | SRRLLKAKTLEIEAC |
| 331 | GMNEALEKQLQELED |
| 339 | QLQELEDKQNADISA |
| 362 | ENELRTTKSEMARYL |
| 370 | SEMARYLKEYQDLLN |
| 91 | KSIRTQEKAQLQDLN |
Function
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity)
Protein Sequence
10
MSSFSYEPYY
20
STSYKRRYVE
30
TPRVHISSVR
40
SGYSTARSAY
50
SSYSAPVSSS
60
LSVRRSYSSS
70
SGSLMPSLEN
80
LDLSQVAAIS
90
NDLKSIRTQE
100
KAQLQDLNDR
110
FASFIERVHE
120
LEQQNKVLEA
130
ELLVLRQKHS
140
EPSRFRALYE
150
QEIRDLRLAA
160
EDATNEKQAL
170
QGEREGLEET
180
LRNLQARYEE
190
EVLSREDAEG
200
RLMEARKGAD
210
EAALARAELE
220
KRIDSLMDEI
230
SFLKKVHEEE
240
IAELQAQIQY
250
AQISVEMDVT
260
KPDLSAALKD
270
IRAQYEKLAA
280
KNMQNAEEWF
290
KSRFTVLTES
300
AAKNTDAVRA
310
AKDEVSESRR
320
LLKAKTLEIE
330
ACRGMNEALE
340
KQLQELEDKQ
350
NADISAMQDT
360
INKLENELRT
370
TKSEMARYLK
380
EYQDLLNVKM
390
ALDIEIAAYR
400
KLLEGEETRL
410
SFTSVGSITS
420
GYSQSSQVFG
430
RSAYGGLQTS
440
SYLMSTRSFP
450
SYYTSHVQEE
460
QIEVEETIEA
470
AKAEEAKDEP
480
PSEGEAEEEE
490
KDKEEAEEEE
500
AAEEEEAAKE
510
ESEEAKEEEE
520
GGEGEEGEET
530
KEAEEEEKKV
540
EGAGEEQAAK
KKD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0098981 | cholinergic synapse |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0005882 | intermediate filament |
| Cellular Component | GO:0005883 | neurofilament |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0099160 | postsynaptic intermediate filament cytoskeleton |
| Cellular Component | GO:0099182 | presynaptic intermediate filament cytoskeleton |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0043274 | phospholipase binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Molecular Function | GO:0099184 | structural constituent of postsynaptic intermediate filament cytoskeleton |
| Molecular Function | GO:0015631 | tubulin binding |
| Biological Process | GO:0008089 | anterograde axonal transport |
| Biological Process | GO:0019896 | axonal transport of mitochondrion |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0021766 | hippocampus development |
| Biological Process | GO:0045109 | intermediate filament organization |
| Biological Process | GO:0045105 | intermediate filament polymerization or depolymerization |
| Biological Process | GO:0033693 | neurofilament bundle assembly |
| Biological Process | GO:0099170 | postsynaptic modulation of chemical synaptic transmission |
| Biological Process | GO:0051258 | protein polymerization |
| Biological Process | GO:0090128 | regulation of synapse maturation |
| Biological Process | GO:1903937 | response to acrylamide |
| Biological Process | GO:0051412 | response to corticosterone |
| Biological Process | GO:0043434 | response to peptide hormone |
| Biological Process | GO:1903935 | response to sodium arsenite |
| Biological Process | GO:0009636 | response to toxic substance |
| Biological Process | GO:0008090 | retrograde axonal transport |
| Biological Process | GO:0021510 | spinal cord development |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.