Search Results
Overview
| Uniprot ID | P07197 |
|---|---|
| Protein Name | Neurofilament medium polypeptide |
| Gene Name | NEFM |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | KLSRSNEKEQLQGLN |
| 118 | RFAGYIEKVHYLEQQ |
| 127 | HYLEQQNKEIEAEIQ |
| 139 | EIQALRQKQASHAQL |
| 208 | AAIRALRKDIEEASL |
| 217 | IEEASLVKVELDKKV |
| 223 | VKVELDKKVQSLQDE |
| 263 | VERKDYLKTDISTAL |
| 271 | TDISTALKEIRSQLE |
| 298 | WFKCRYAKLTEAAEQ |
| 307 | TEAAEQNKEAIRSAK |
| 314 | KEAIRSAKEEIAEYR |
| 327 | YRRQLQSKSIELESV |
| 391 | YQDLLNVKMALDIEI |
| 451 | PKLKVQHKFVEEIIE |
| 53 | STVSSSYKRSMLAPR |
| 619 | KAKSPVPKSPVEEKG |
| 671 | KGKSPVSKSPVEEKA |
| 684 | KAKSPVPKSPVEEAK |
| 754 | VTITKSVKVHLEKET |
| 759 | SVKVHLEKETKEEGK |
| 842 | DLSPADEKKGGDKSE |
| 851 | GGDKSEEKVVVTKTV |
| 871 | EGGDGATKYITKSVT |
| 875 | GATKYITKSVTVTQK |
| 893 | HEETFEEKLVSTKKV |
| 902 | VSTKKVEKVTSHAIV |
| 910 | VTSHAIVKEVTQSD* |
Function
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity)
Protein Sequence
10
MSYTLDSLGN
20
PSAYRRVTET
30
RSSFSRVSGS
40
PSSGFRSQSW
50
SRGSPSTVSS
60
SYKRSMLAPR
70
LAYSSAMLSS
80
AESSLDFSQS
90
SSLLNGGSGP
100
GGDYKLSRSN
110
EKEQLQGLND
120
RFAGYIEKVH
130
YLEQQNKEIE
140
AEIQALRQKQ
150
ASHAQLGDAY
160
DQEIRELRAT
170
LEMVNHEKAQ
180
VQLDSDHLEE
190
DIHRLKERFE
200
EEARLRDDTE
210
AAIRALRKDI
220
EEASLVKVEL
230
DKKVQSLQDE
240
VAFLRSNHEE
250
EVADLLAQIQ
260
ASHITVERKD
270
YLKTDISTAL
280
KEIRSQLESH
290
SDQNMHQAEE
300
WFKCRYAKLT
310
EAAEQNKEAI
320
RSAKEEIAEY
330
RRQLQSKSIE
340
LESVRGTKES
350
LERQLSDIEE
360
RHNHDLSSYQ
370
DTIQQLENEL
380
RGTKWEMARH
390
LREYQDLLNV
400
KMALDIEIAA
410
YRKLLEGEET
420
RFSTFAGSIT
430
GPLYTHRPPI
440
TISSKIQKPK
450
VEAPKLKVQH
460
KFVEEIIEET
470
KVEDEKSEME
480
EALTAITEEL
490
AVSMKEEKKE
500
AAEEKEEEPE
510
AEEEEVAAKK
520
SPVKATAPEV
530
KEEEGEKEEE
540
EGQEEEEEED
550
EGAKSDQAEE
560
GGSEKEGSSE
570
KEEGEQEEGE
580
TEAEAEGEEA
590
EAKEEKKVEE
600
KSEEVATKEE
610
LVADAKVEKP
620
EKAKSPVPKS
630
PVEEKGKSPV
640
PKSPVEEKGK
650
SPVPKSPVEE
660
KGKSPVPKSP
670
VEEKGKSPVS
680
KSPVEEKAKS
690
PVPKSPVEEA
700
KSKAEVGKGE
710
QKEEEEKEVK
720
EAPKEEKVEK
730
KEEKPKDVPE
740
KKKAESPVKE
750
EAVAEVVTIT
760
KSVKVHLEKE
770
TKEEGKPLQQ
780
EKEKEKAGGE
790
GGSEEEGSDK
800
GAKGSRKEDI
810
AVNGEVEGKE
820
EVEQETKEKG
830
SGREEEKGVV
840
TNGLDLSPAD
850
EKKGGDKSEE
860
KVVVTKTVEK
870
ITSEGGDGAT
880
KYITKSVTVT
890
QKVEEHEETF
900
EEKLVSTKKV
910
EKVTSHAIVK
EVTQSD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005882 | intermediate filament |
| Cellular Component | GO:0045111 | intermediate filament cytoskeleton |
| Cellular Component | GO:0097418 | neurofibrillary tangle |
| Cellular Component | GO:0005883 | neurofilament |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0099160 | postsynaptic intermediate filament cytoskeleton |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0033693 | neurofilament bundle assembly |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.