Search Results
Overview
| Uniprot ID | P07205 |
|---|---|
| Protein Name | Phosphoglycerate kinase 2 |
| Gene Name | PGK2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 11 | SKKLTLDKLDVRGKR |
| 141 | DPSGKKIKAEPDKIE |
| 192 | ASGFLMKKELDYFAK |
| 220 | GGAKVADKIQLIKNM |
| 267 | EEGAKIVKDIMAKAQ |
| 272 | IVKDIMAKAQKNGVR |
| 31 | DFNVPMKKNQITNNQ |
| 322 | DCGPESNKNHAQVVA |
| 353 | DAFAKGTKALMDEIV |
| 41 | ITNNQRIKASIPSIK |
| 6 | **MSLSKKLTLDKLD |
| 91 | ELKSLLGKDVLFLKD |
Function
Catalyzes the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate and plays a role in glycolysis and gluconeogenesis (By similarity). Essential for sperm motility and male fertility (PubMed:26677959). Not required for the completion of spermatogenesis (By similarity)
Protein Sequence
10
MSLSKKLTLD
20
KLDVRGKRVI
30
MRVDFNVPMK
40
KNQITNNQRI
50
KASIPSIKYC
60
LDNGAKAVVL
70
MSHLGRPDGV
80
PMPDKYSLAP
90
VAVELKSLLG
100
KDVLFLKDCV
110
GAEVEKACAN
120
PAPGSVILLE
130
NLRFHVEEEG
140
KGQDPSGKKI
150
KAEPDKIEAF
160
RASLSKLGDV
170
YVNDAFGTAH
180
RAHSSMVGVN
190
LPHKASGFLM
200
KKELDYFAKA
210
LENPVRPFLA
220
ILGGAKVADK
230
IQLIKNMLDK
240
VNEMIIGGGM
250
AYTFLKVLNN
260
MEIGASLFDE
270
EGAKIVKDIM
280
AKAQKNGVRI
290
TFPVDFVTGD
300
KFDENAQVGK
310
ATVASGISPG
320
WMGLDCGPES
330
NKNHAQVVAQ
340
ARLIVWNGPL
350
GVFEWDAFAK
360
GTKALMDEIV
370
KATSKGCITV
380
IGGGDTATCC
390
AKWNTEDKVS
400
HVSTGGGASL
410
ELLEGKILPG
VEALSNM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0035686 | sperm fibrous sheath |
| Molecular Function | GO:0043531 | ADP binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004618 | phosphoglycerate kinase activity |
| Biological Process | GO:0061621 | canonical glycolysis |
| Biological Process | GO:0006094 | gluconeogenesis |
| Biological Process | GO:0006096 | glycolytic process |
| Biological Process | GO:0016310 | phosphorylation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.