Overview
| Uniprot ID | P07306 |
|---|
| Protein Name | Asialoglycoprotein receptor 1 |
|---|
| Gene Name | ASGR1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 3 |
*****MTKEYQDLQH |
Function
Transmembrane protein predominantly expressed on hepatocytes that plays a key role in endocytosis of plasma glycoproteins that lack terminal sialic acid residues. Specifically recognizes terminal galactose and N-acetylgalactosamine residues, facilitating the clearance of desialylated glycoproteins from circulation. Plays thereby a role in a variety of physiological processes, such as removal of desialylated platelets, elimination of activated lymphocytes and maintenance of serum glycoprotein homeostasis (PubMed:25485912). Plays a role in the removal of desialylated platelets by activating a feedback loop regulating thrombopoietin (TPO) expression via the JAK2-STAT3 signaling pathway (PubMed:25485912). Contributes also to recognition and elimination of activated lymphocytes by hepatocytes that can act as cytotoxic effectors (PubMed:21656538). May also play a physiological role in the regulatory network of lipid homeostasis (By similarity). Upon ligand binding, the receptor-ligand complex is internalized and trafficked to a sorting organelle, where dissociation occurs. The receptor is then recycled back to the cell surface
Protein Sequence
10
MTKEYQDLQH
20
LDNEESDHHQ
30
LRKGPPPPQP
40
LLQRLCSGPR
50
LLLLSLGLSL
60
LLLVVVCVIG
70
SQNSQLQEEL
80
RGLRETFSNF
90
TASTEAQVKG
100
LSTQGGNVGR
110
KMKSLESQLE
120
KQQKDLSEDH
130
SSLLLHVKQF
140
VSDLRSLSCQ
150
MAALQGNGSE
160
RTCCPVNWVE
170
HERSCYWFSR
180
SGKAWADADN
190
YCRLEDAHLV
200
VVTSWEEQKF
210
VQHHIGPVNT
220
WMGLHDQNGP
230
WKWVDGTDYE
240
TGFKNWRPEQ
250
PDDWYGHGLG
260
GGEDCAHFTD
270
DGRWNDDVCQ
280
RPYRWVCETE
290
LDKASQEPPL
L
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009897 |
external side of plasma membrane |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0004873 |
asialoglycoprotein receptor activity |
| Molecular Function |
GO:0005537 |
D-mannose binding |
| Molecular Function |
GO:0042806 |
fucose binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0038187 |
pattern recognition receptor activity |
| Biological Process |
GO:0006955 |
immune response |
| Biological Process |
GO:0006898 |
receptor-mediated endocytosis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.